Abstract Three-dimensional (3D) stem cell culture systems have attracted considerable
attention as a way to better mimic the complex interactions between individual cells and the …

The field of tissue engineering has produced new therapies for the repair of damaged
tissues and organs, utilizing biomimetic scaffolds that mirror the mechanical and biological …

The great demand for tissue and organ grafts, compounded by an aging demographic and a
shortage of available donors, has driven the development of bioengineering approaches …

Scaffold-free spheroids offer great potential as a direct supply of cells for bottom-up bone
tissue engineering. However, the building of functional spheroids with both cells and …

A simplified and cost-effective culture system for maintaining the pluripotency of human
induced pluripotent stem cells (hiPSCs) is crucial for stem cell applications. Although …

Stem cells demonstrate considerable promise for various preclinical and clinical
applications, including drug screening, disease treatments, and regenerative medicine …

Nature has created many perfect helical microstructures, including DNA, collagen fibrils, and
helical blood vessels, to achieve unique physiological functions. While previous studies …

Although stem cell spheroids offer great potential as functional building blocks for bottom-up
bone tissue engineering, delivery of bioactive signals remain challenging. Here, we …

To date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly
hampered by the lack of suitable disease models. Indeed, animal models do not faithfully …

Abstract 3D cellular spheroids offer more biomimetic microenvironments than conventional
2D cell culture technologies, which has proven value for many tissue engineering …