HIV-associated nephropathies: epidemiology, pathology, mechanisms and treatment

AZ Rosenberg, S Naicker, CA Winkler… - Nature Reviews …, 2015 - nature.com
HIV is a highly adaptive, rapidly evolving virus, which is associated with renal diseases
including collapsing glomerulopathy—the classic histomorphological form of HIV-associated …

[HTML][HTML] Scar wars: mapping the fate of epithelial–mesenchymal–myofibroblast transition

SE Quaggin, A Kapus - Kidney international, 2011 - Elsevier
The hypothesis that epithelial–mesenchymal transition (EMT) might be a contributor to the
accumulation of fibroblasts and myofibroblasts (MFs) in the kidney during fibrogenesis was …

Resolved: EMT produces fibroblasts in the kidney

M Zeisberg - Journal of the American Society of Nephrology, 2010 - journals.lww.com
Epithelial-mesenchymal transition (EMT) is a mechanism for generating primitive
mesenchymal cells during gastrulation or mobile tumor cells during cancer metastasis. For …

A systems approach identifies HIPK2 as a key regulator of kidney fibrosis

Y Jin, K Ratnam, PY Chuang, Y Fan, Y Zhong, Y Dai… - Nature medicine, 2012 - nature.com
Kidney fibrosis is a common process that leads to the progression of various types of kidney
disease. We used an integrated computational and experimental systems biology approach …

S100A4+ macrophages facilitate zika virus invasion and persistence in the seminiferous tubules via interferon-gamma mediation

W Yang, YH Wu, SQ Liu, ZY Sheng, ZD Zhen… - PLoS …, 2020 - journals.plos.org
Testicular invasion and persistence are features of Zika virus (ZIKV), but their mechanisms
are still unknown. Here, we showed that S100A4+ macrophages, a myeloid macrophage …

Glomerular parietal epithelial cells in kidney physiology, pathology, and repair

SJ Shankland, HJ Anders… - Current opinion in …, 2013 - journals.lww.com
Glomerular parietal epithelial cells in kidney physiology, p... : Current Opinion in Nephrology
and Hypertension Glomerular parietal epithelial cells in kidney physiology, pathology, and …

S100A4 Promotes BCG-Induced Pyroptosis of Macrophages by Activating the NF-κB/NLRP3 Inflammasome Signaling Pathway

M Li, Y Liu, X Nie, B Ma, Y Ma, Y Hou, Y Yang… - International Journal of …, 2023 - mdpi.com
Pyroptosis is a host immune strategy to defend against Mycobacterium tuberculosis (Mtb)
infection. S100A4, a calcium-binding protein that plays an important role in promoting …

HIV-1 proteins gp120 and tat induce the epithelial–mesenchymal transition in oral and genital mucosal epithelial cells

K Lien, W Mayer, R Herrera, K Rosbe, SM Tugizov - PLoS One, 2019 - journals.plos.org
The oral, cervical, and genital mucosa, covered by stratified squamous epithelia with
polarized organization and strong tight and adherens junctions, play a critical role in …

[HTML][HTML] Compound effects of aging and experimental FSGS on glomerular epithelial cells

RRS Schneider, DG Eng, JN Kutz… - Aging (Albany …, 2017 - ncbi.nlm.nih.gov
Advanced age portends a poorer prognosis in FSGS. To understand the impact of age on
glomerular podocytes and parietal epithelial cells (PECs), experimental FSGS was induced …

HIV‐1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS‐Dependent Upregulation of Twist

E Bayurova, J Jansons, D Skrastina… - Oxidative Medicine …, 2019 - Wiley Online Library
HIV‐induced immune suppression results in the high prevalence of HIV/AIDS‐associated
malignancies including Kaposi sarcoma, non‐Hodgkin lymphoma, and cervical cancer. HIV …