Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Phenotypic and functional heterogeneity arise among cancer cells within the same tumour
as a consequence of genetic change, environmental differences and reversible changes in …

Over the last decade, the notion that tumors are maintained by their own stem cells, the so-
called cancer stem cells, has created great excitement in the research community. This …

The differentiation of tumorigenic cancer stem cells into nontumorigenic cancer cells confers
heterogeneity to some cancers beyond that explained by clonal evolution or environmental …

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

The identification and characterization of cancer stem cells might lead to more effective
treatments for some cancers by focusing therapy on the most malignant cells. To achieve …

Eighty percent of malignant tumors that develop in the central nervous system are malignant
gliomas, which are essentially incurable. Here, we discuss how recent sequencing studies …

Growth of numerous cancer types is believed to be driven by a subpopulation of poorly
differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for …

The identification of lung tumor-initiating cells and associated markers may be useful for
optimization of therapeutic approaches and for predictive and prognostic information in lung …

Cancer stem cells (CSCs) are a subpopulation of tumor cells suggested to be critical for
tumor maintenance, metastasis, and therapeutic resistance. Prospective identification and …