[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …
Update on adipose tissue and cancer
KA Brown, PE Scherer - Endocrine reviews, 2023 - academic.oup.com
Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in
disease progression is unclear. We investigated the role of lipid metabolism in prostate …
disease progression is unclear. We investigated the role of lipid metabolism in prostate …
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer
G Zadra, CF Ribeiro, P Chetta, Y Ho… - Proceedings of the …, 2019 - National Acad Sciences
A hallmark of prostate cancer progression is dysregulation of lipid metabolism via
overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis …
overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis …
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
JA Menendez, R Lupu - Nature Reviews Cancer, 2007 - nature.com
There is a renewed interest in the ultimate role of fatty acid synthase (FASN)—a key
lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids—in …
lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids—in …
Fatty acid synthase as a potential therapeutic target in cancer
Fatty acid synthase (FASN) is a key enzyme involved in neoplastic lipogenesis.
Overexpression of FASN is common in many cancers, and accumulating evidence suggests …
Overexpression of FASN is common in many cancers, and accumulating evidence suggests …
[HTML][HTML] Lipid metabolism in prostate cancer
X Wu, G Daniels, P Lee, ME Monaco - American journal of clinical …, 2014 - ncbi.nlm.nih.gov
The malignant transformation of cells requires adaptations across multiple metabolic
processes to satisfy the energy required for their increased rate of proliferation …
processes to satisfy the energy required for their increased rate of proliferation …
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer
(PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic …
(PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic …
Resolving the immune landscape of human prostate at a single-cell level in health and cancer
The prostate gland produces prostatic fluid, high in zinc and citrate and essential for the
maintenance of spermatozoa. Prostate cancer is a common condition with limited treatment …
maintenance of spermatozoa. Prostate cancer is a common condition with limited treatment …
Increased lipogenesis in cancer cells: new players, novel targets
JV Swinnen, K Brusselmans… - Current Opinion in …, 2006 - journals.lww.com
The same disturbances in signaling pathways responsible for oncogenic transformation may
also contribute to the increased lipogenesis observed in tumor cells. Increased lipogenesis …
also contribute to the increased lipogenesis observed in tumor cells. Increased lipogenesis …