With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …

Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in
disease progression is unclear. We investigated the role of lipid metabolism in prostate …

A hallmark of prostate cancer progression is dysregulation of lipid metabolism via
overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis …

There is a renewed interest in the ultimate role of fatty acid synthase (FASN)—a key
lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids—in …

Fatty acid synthase (FASN) is a key enzyme involved in neoplastic lipogenesis.
Overexpression of FASN is common in many cancers, and accumulating evidence suggests …

The malignant transformation of cells requires adaptations across multiple metabolic
processes to satisfy the energy required for their increased rate of proliferation …

Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer
(PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic …

The prostate gland produces prostatic fluid, high in zinc and citrate and essential for the
maintenance of spermatozoa. Prostate cancer is a common condition with limited treatment …

The same disturbances in signaling pathways responsible for oncogenic transformation may
also contribute to the increased lipogenesis observed in tumor cells. Increased lipogenesis …