Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …

The NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) transcription factor
family is a pleiotropic regulator of many cellular signaling pathways, providing a mechanism …

Since the initial description of apoptosis, a number of different forms of cell death have been
described. In this review we will focus on classic caspase-dependent apoptosis and its …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Different animal and human studies from last two decades in the case of Parkinson's
disease (PD) have concentrated on oxidative stress due to increased inflammation and …

Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …

The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …

Background and Purpose—Sirtuin 1 (SIRT1) is a member of NAD+-dependent protein
deacetylases implicated in a wide range of cellular functions and has beneficial properties in …

SARS-CoV-2 is a betacoronavirus causing severe inflammatory pneumonia, so that
excessive inflammation is considered a risk factor for the disease. According to reports …

The NF-κB family of dimeric transcription factors regulates transcription by selectively
binding to DNA response elements present within promoters or enhancers of target genes …