Asiaticoside polymeric nanoparticles for effective diabetic wound healing through increased collagen biosynthesis: In-vitro and in-vivo evaluation

S Narisepalli, SA Salunkhe, D Chitkara… - International Journal of …, 2023 - Elsevier
Asiaticoside (AST) is a naturally available phytoconstituent that enables effective wound
healing mainly by promoting collagen biosynthesis. However, the physicochemical nature of …

Nanosuspension-loaded dissolving bilayer microneedles for hydrophobic drug delivery to the posterior segment of the eye

Y Wu, LK Vora, D Mishra, MF Adrianto, S Gade… - Biomaterials …, 2022 - Elsevier
Intravitreal injections (IVT) are regarded as the gold standard for effective delivery of
hydrophobic drugs to the back of the eye. However, as a highly invasive procedure, the …

Advanced modification of drug nanocrystals by using novel fabrication and downstream approaches for tailor-made drug delivery

T Liu, X Yu, H Yin, JP Möschwitzer - Drug delivery, 2019 - Taylor & Francis
Drug nanosuspensions/nanocrystals have been recognized as one useful and successful
approach for drug delivery. Drug nanocrystals could be further decorated to possess …

[HTML][HTML] Metronidazole nanosuspension loaded dissolving microarray patches: An engineered composite pharmaceutical system for the treatment of skin and soft …

QK Anjani, AHB Sabri, J Domínguez-Robles… - Biomaterials …, 2022 - Elsevier
Bacteroides fragilis is one of the most common causative group of microorganisms that is
associated with skin and soft tissue infections (SSTI). Metronidazole (MTZ) is the drug of …

Combination of dissolving microneedles with nanosuspension and co-grinding for transdermal delivery of ketoprofen

D Ramadon, F Ulayya, AS Qur'ani, I Iskandarsyah… - Pharmaceuticals, 2023 - mdpi.com
Ketoprofen is an anti-inflammatory agent that may cause gastric irritation if administered
orally. Dissolving microneedles (DMN) can be a promising strategy to overcome this issue …

Examine stability polyvinyl alcohol-stabilized nanosuspensions to overcome the challenge of poor drug solubility utilizing molecular dynamic simulation

S Abdollahi, H Raissi, F Farzad - Scientific Reports, 2024 - nature.com
The pharmaceutical industry faces a significant challenge from the low water solubility of
nearly 90% of newly developed Active Pharmaceutical Ingredients (APIs). Despite extensive …

[HTML][HTML] Development of extra-fine particles containing nanosized meloxicam for deep pulmonary delivery: In vitro aerodynamic and cell line measurements

P Party, D Kókai, K Burián, A Nagy, B Hopp… - European Journal of …, 2022 - Elsevier
Pulmonary drug administration provides a platform for the effective local treatment of various
respiratory diseases. Application of nano-sized active ingredients results in higher …

[HTML][HTML] Deferasirox nanosuspension loaded dissolving microneedles for ocular drug delivery

HS Faizi, MI Nasiri, Y Wu, D Mishra, RF Donnelly… - International Journal of …, 2024 - Elsevier
Deferasirox (DFS) is an oral iron chelator that is employed in retinal ailments as a
neuroprotectant against retinal injury and thus has utility in treating disorders such as …

Smartcrystals for efficient dissolution of poorly water-soluble meloxicam

R Ambrus, A Alshweiat, P Szabó-Révész, C Bartos… - Pharmaceutics, 2022 - mdpi.com
Nanocrystal is widely applied to improve the dissolution of poorly water-soluble drugs. We
aimed to prepare meloxicam (MLX) nanocrystals using the bead mill method, followed by …

Recent advances in techniques for enhancing the solubility of hydrophobic drugs.

Z Xu, S Lin, Q Li, S Jiang, P Wang - Pakistan Journal of …, 2022 - go.gale.com
Numerous hydrophobic compounds are important ingredients for drug discovery and
development. Hydrophobicity has been a major hurdle limiting the therapeutic efficacy of …