Asiaticoside polymeric nanoparticles for effective diabetic wound healing through increased collagen biosynthesis: In-vitro and in-vivo evaluation
Asiaticoside (AST) is a naturally available phytoconstituent that enables effective wound
healing mainly by promoting collagen biosynthesis. However, the physicochemical nature of …
healing mainly by promoting collagen biosynthesis. However, the physicochemical nature of …
Nanosuspension-loaded dissolving bilayer microneedles for hydrophobic drug delivery to the posterior segment of the eye
Intravitreal injections (IVT) are regarded as the gold standard for effective delivery of
hydrophobic drugs to the back of the eye. However, as a highly invasive procedure, the …
hydrophobic drugs to the back of the eye. However, as a highly invasive procedure, the …
Advanced modification of drug nanocrystals by using novel fabrication and downstream approaches for tailor-made drug delivery
T Liu, X Yu, H Yin, JP Möschwitzer - Drug delivery, 2019 - Taylor & Francis
Drug nanosuspensions/nanocrystals have been recognized as one useful and successful
approach for drug delivery. Drug nanocrystals could be further decorated to possess …
approach for drug delivery. Drug nanocrystals could be further decorated to possess …
[HTML][HTML] Metronidazole nanosuspension loaded dissolving microarray patches: An engineered composite pharmaceutical system for the treatment of skin and soft …
QK Anjani, AHB Sabri, J Domínguez-Robles… - Biomaterials …, 2022 - Elsevier
Bacteroides fragilis is one of the most common causative group of microorganisms that is
associated with skin and soft tissue infections (SSTI). Metronidazole (MTZ) is the drug of …
associated with skin and soft tissue infections (SSTI). Metronidazole (MTZ) is the drug of …
Combination of dissolving microneedles with nanosuspension and co-grinding for transdermal delivery of ketoprofen
D Ramadon, F Ulayya, AS Qur'ani, I Iskandarsyah… - Pharmaceuticals, 2023 - mdpi.com
Ketoprofen is an anti-inflammatory agent that may cause gastric irritation if administered
orally. Dissolving microneedles (DMN) can be a promising strategy to overcome this issue …
orally. Dissolving microneedles (DMN) can be a promising strategy to overcome this issue …
Examine stability polyvinyl alcohol-stabilized nanosuspensions to overcome the challenge of poor drug solubility utilizing molecular dynamic simulation
S Abdollahi, H Raissi, F Farzad - Scientific Reports, 2024 - nature.com
The pharmaceutical industry faces a significant challenge from the low water solubility of
nearly 90% of newly developed Active Pharmaceutical Ingredients (APIs). Despite extensive …
nearly 90% of newly developed Active Pharmaceutical Ingredients (APIs). Despite extensive …
[HTML][HTML] Development of extra-fine particles containing nanosized meloxicam for deep pulmonary delivery: In vitro aerodynamic and cell line measurements
Pulmonary drug administration provides a platform for the effective local treatment of various
respiratory diseases. Application of nano-sized active ingredients results in higher …
respiratory diseases. Application of nano-sized active ingredients results in higher …
[HTML][HTML] Deferasirox nanosuspension loaded dissolving microneedles for ocular drug delivery
Deferasirox (DFS) is an oral iron chelator that is employed in retinal ailments as a
neuroprotectant against retinal injury and thus has utility in treating disorders such as …
neuroprotectant against retinal injury and thus has utility in treating disorders such as …
Smartcrystals for efficient dissolution of poorly water-soluble meloxicam
R Ambrus, A Alshweiat, P Szabó-Révész, C Bartos… - Pharmaceutics, 2022 - mdpi.com
Nanocrystal is widely applied to improve the dissolution of poorly water-soluble drugs. We
aimed to prepare meloxicam (MLX) nanocrystals using the bead mill method, followed by …
aimed to prepare meloxicam (MLX) nanocrystals using the bead mill method, followed by …
Recent advances in techniques for enhancing the solubility of hydrophobic drugs.
Z Xu, S Lin, Q Li, S Jiang, P Wang - Pakistan Journal of …, 2022 - go.gale.com
Numerous hydrophobic compounds are important ingredients for drug discovery and
development. Hydrophobicity has been a major hurdle limiting the therapeutic efficacy of …
development. Hydrophobicity has been a major hurdle limiting the therapeutic efficacy of …