Ventricular arrhythmias are a major cause of sudden death, which accounts for
approximately half of cardiac mortality. The His–Purkinje system is composed of specialized …

Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling.
Intracellular Ca2+ concentration increases during systole and falls in diastole thereby …

The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic
reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In …

Idiopathic ventricular fibrillation is responsible for approximately 5%-7% of cases of aborted
cardiac arrest. Recent studies have shown that short-coupled ventricular premature …

2 Visser et al IVF: Definition, Diagnosis, and Follow-Up familial inheritance of a malign ER
pattern have been identified. 15 Therefore, ERS is considered a separate disease entity that …

Background Ventricular fibrillation may be caused by premature ventricular contractions
(PVCs) whose coupling intervals are< 300 ms, a characteristic of the short-coupled variant of …

Background Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease
associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac …

570 Circ Cardiovasc Genet December 2016 potassium channel dysfunction has also been
proposed recently as a possible mechanism for some stillbirths given that LQTS …

Background: Sarcoplasmic reticulum Ca2+ leak and post-translational modifications under
stress have been implicated in catecholaminergic polymorphic ventricular tachycardia …

The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain
normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular …