Atrial cardiomyocytes make an important contribution to the refilling of ventricles with blood,
which enhances the subsequent ejection of blood from the heart. The dependence of …

Whereas Ca2+ signalling in ventricular cardiomyocytes is well described, much less is
known regarding the Ca2+ signals within atrial cells. This is surprising given that atrial …

Age‐dependent changes in the architecture of the sinus node comprise an increasing ratio
between fibroblasts and cardiomyocytes. This change is discussed as a potential …

Embryonic stem cell‐derived cardiomyocytes (ESdCs) have been proposed as a source for
cardiac cell‐replacement therapy. The aim of this study was to determine the Ca2+‐handling …

Therapies for heart disease are based largely on our understanding of the adult
myocardium. The dramatic differences in action potential (AP) shape between neonatal and …

We have followed the differentiation of transverse (T) tubules and of the associations
between sarcoplasmic reticulum (SR) and either the plasmalemma (peripheral couplings) or …

Abstract Background Calcium signals ([Ca 2+] i) direct many aspects of embryo
development but their regulation is not well characterised. Ryanodine receptors (RyRs) are …

Mechanisms of cardiac excitation-contraction coupling in neonates are still not clearly
defined. Previous work in neonates shows reverse-mode Na+-Ca 2+ exchange to be the …

Calcium sparks result from the concerted opening of a small number of Ca2+ release
channels (ryanodine receptors, RyRs) organized in clusters in the membrane of the …

Understanding how the nervous system bridges sensation and behavior requires the
elucidation of complex neural and molecular networks. Forward genetic approaches, such …