Phagocytosis is a fundamental process of cells to capture and ingest foreign particles. Small
unicellular organisms such as free-living amoeba use this process to acquire food. In …

Abstract Urease (urea amidohydrolase, EC 3.5. 1.5) is a nickel-containing enzyme produced
by plants, fungi, and bacteria that catalyzes the hydrolysis of urea into ammonia and …

Ammonia is diffused and transported across all plasma membranes. This entails that
hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that …

ABSTRACT pH homeostasis is critical for all organisms; in the fungal pathogen Candida
albicans, pH adaptation is critical for virulence in distinct host niches. We demonstrate that …

The ability of microorganisms to sense and adapt to changes in the environment is essential
to their survival. This is particularly important for species with an intimate association with …

Urea is generated in humans following the breakdown of amino acids and is evenly
distributed throughout the body, including in the central nervous system, subcutaneous …

Cryptococcus neoformans is a facultative intracellular pathogen and its interaction with
macrophages is a key event determining the outcome of infection. Urease is a major …

The fungus Cryptococcus neoformans is the causative agent of cryptococcosis, a disease
that is uniformly lethal unless treated with antifungal drugs, yet current regimens are …

Ureases are metalloenzymes that hydrolyze urea into ammonia and carbon dioxide. They
were the first enzymes to be crystallized and, with them, the notion that enzymes are proteins …

The Sporothrix complex members cause sporotrichosis, a subcutaneous mycosis with a
wide spectrum of clinical manifestations. Several specific phenotypic characteristics are …