Emerging computational methods in mass spectrometry imaging

H Hu, J Laskin - Advanced Science, 2022 - Wiley Online Library
Mass spectrometry imaging (MSI) is a powerful analytical technique that generates maps of
hundreds of molecules in biological samples with high sensitivity and molecular specificity …

High-throughput mass spectrometry imaging of biological systems: Current approaches and future directions

LX Jiang, M Yang, SN Wali, J Laskin - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
In the past two decades, the power of mass spectrometry imaging (MSI) for the label free
spatial mapping of molecules in biological systems has been substantially enhanced by the …

High-throughput mass spectrometry imaging with dynamic sparse sampling

H Hu, D Helminiak, M Yang, D Unsihuay… - ACS Measurement …, 2022 - ACS Publications
Mass spectrometry imaging (MSI) enables label-free mapping of hundreds of molecules in
biological samples with high sensitivity and unprecedented specificity. Conventional MSI …

Recent advances in mass spectrometry imaging combined with artificial intelligence for spatially clarifying molecular profiles: Toward biomedical applications

H Zhang, J Zhang, C Yuan, D Zhang, D Lu… - TrAC Trends in …, 2024 - Elsevier
Mass spectrometry imaging (MSI) is an intuitive and multidimensional analysis method that
provides spatial information on molecules in tissues or cells; it is widely used in biomedical …

Enhancing the throughput of FT mass spectrometry imaging using joint compressed sensing and subspace modeling

YR Xie, DC Castro, SS Rubakhin… - Analytical …, 2022 - ACS Publications
Mass spectrometry imaging (MSI) allows for untargeted mapping of the chemical
composition of tissues with attomole detection limits. MSI using Fourier transform (FT)-based …

Multiscale biochemical mapping of the brain through deep-learning-enhanced high-throughput mass spectrometry

YR Xie, DC Castro, SS Rubakhin, TJ Trinklein… - Nature …, 2024 - nature.com
Spatial omics technologies can reveal the molecular intricacy of the brain. While mass
spectrometry imaging (MSI) provides spatial localization of compounds, comprehensive …

[HTML][HTML] Integrative Multiscale Biochemical Mapping of the Brain via Deep-Learning-Enhanced High-Throughput Mass Spectrometry

YR Xie, DC Castro, SS Rubakhin, TJ Trinklein… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Elucidating the spatial-biochemical organization of the brain across different scales
produces invaluable insight into the molecular intricacy of the brain. While mass …

Polymerization as a strategy to improve small organic matrices for low-molecular-weight compound analytics with MALDI MS and MALDI MS imaging

K Horatz, M Giampà, Z Qiao, SA Moestue… - ACS applied polymer …, 2021 - ACS Publications
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) and the
corresponding visualizing technique MALDI MS imaging (MSI) are potent and widely used …

Mass spectrometry imaging of fibroblasts: Promise and challenge

PM Angel, D Rujchanarong, S Pippin… - Expert review of …, 2021 - Taylor & Francis
Introduction Fibroblasts maintain tissue and organ homeostasis through output of
extracellular matrix that affects nearby cell signaling within the stroma. Altered fibroblast …

Instantaneous Frequency Estimation via an Adaptive Mode Decomposition for Mass Spectrometry

S Smith - 2022 - search.proquest.com
Current analytical mass spectrometry instrumentation that is used for the study of complex
mixtures (eg, proteins, environmental samples, petroleum, biological small molecules), is …