Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism,
biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated …

Hydrogen peroxide, the nonradical 2-electron reduction product of oxygen, is a normal
aerobic metabolite occurring at about 10 nm intracellular concentration. In liver, it is …

Reactive oxygen species (ROS) are chemically reactive molecules that are naturally
produced within biological systems. Research has focused extensively on revealing the …

Although historically viewed as purely harmful, recent evidence suggests that reactive
oxygen species (ROS) function as important physiological regulators of intracellular …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Chromium (Cr) is the second most common metal contaminant in ground water, soil, and
sediments due to its wide industrial application, hence posing a serious environmental …

The first suggestion that physical exercise results in free radical-mediated damage to tissues
appeared in 1978, and the past three decades have resulted in a large growth of knowledge …

Peroxiredoxins (Prxs) are a very large and highly conserved family of peroxidases that
reduce peroxides, with a conserved cysteine residue, designated the “peroxidatic” Cys (CP) …

Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …

Peroxiredoxins (Prxs) contain an active site cysteine that is sensitive to oxidation by H 2 O 2.
Mammalian cells express six Prx isoforms that are localized to various cellular …