Adhesion G protein-coupled receptors (aGPCRs) constitute an evolutionarily ancient family
of receptors that often undergo autoproteolysis to produce α and β subunits,–. A tethered …

Adhesion G-protein-coupled receptors (aGPCRs) are important for organogenesis,
neurodevelopment, reproduction and other processes,,,,–. Many aGPCRs are activated by a …

Glucose homeostasis, regulated by glucose-dependent insulinotropic polypeptide (GIP),
glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical to human health. Several …

The activation of G protein-coupled receptors (GPCRs) is triggered by ligand binding to their
orthosteric sites, which induces ligand-specific conformational changes. Agonists and …

In Covid-19, systemic disturbances may progress due to development of cytokine storm and
dysregulation of and plasma osmolarility due to high release of pro-inflammatory cytokines …

Arrestins interact with G protein–coupled receptors (GPCRs) to stop G protein activation and
to initiate key signaling pathways. Recent structural studies shed light on the molecular …

Cholecystokinin A receptor (CCKAR) belongs to family A G-protein-coupled receptors and
regulates nutrient homeostasis upon stimulation by cholecystokinin (CCK). It is an attractive …

Oxytocin (OT) and vasopressin (AVP) are conserved peptide signaling hormones that are
critical for diverse processes including osmotic homeostasis, reproduction, lactation and …

Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and
attractive targets for various diseases. aGPCRs are also known to be capable of self …

Adhesion G protein-coupled receptors are elusive in terms of their structural information and
ligands. Here, we solved the cryogenic-electron microscopy (cryo-EM) structure of apo …