Immortalized dorsal root ganglion neuron cell lines
Pain is one of the most significant causes of suffering and disability world-wide, and
arguably the most burdensome global health challenge. The growing number of patients …
arguably the most burdensome global health challenge. The growing number of patients …
[PDF][PDF] Molecular basis of TRPA1 regulation in nociceptive neurons. A review.
A Kádková, V Synytsya, J Krusek, L Zímová… - Physiological …, 2017 - researchgate.net
Transient receptor potential A1 (TRPA1) is an excitatory ion channel that functions as a
cellular sensor, detecting a wide range of proalgesic agents such as environmental irritants …
cellular sensor, detecting a wide range of proalgesic agents such as environmental irritants …
Macrophage angiotensin II type 2 receptor triggers neuropathic pain
AJ Shepherd, AD Mickle, JP Golden… - Proceedings of the …, 2018 - National Acad Sciences
Peripheral nerve damage initiates a complex series of structural and cellular processes that
culminate in chronic neuropathic pain. The recent success of a type 2 angiotensin II (Ang II) …
culminate in chronic neuropathic pain. The recent success of a type 2 angiotensin II (Ang II) …
Angiotensin II triggers peripheral macrophage-to-sensory neuron redox crosstalk to elicit pain
Injury, inflammation, and nerve damage initiate a wide variety of cellular and molecular
processes that culminate in hyperexcitation of sensory nerves, which underlies chronic …
processes that culminate in hyperexcitation of sensory nerves, which underlies chronic …
Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons
C Di Primio, P Quaranta, M Mignanelli, G Siano… - PNAS …, 2023 - academic.oup.com
COVID-19 has represented an issue for global health since its outbreak in March 2020. It is
now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are
targeted by many toxins that directly interact with the pore-forming α subunit, typically via …
targeted by many toxins that directly interact with the pore-forming α subunit, typically via …
Dorsal root ganglia isolation and primary culture to study neurotransmitter release
YT Lin, JC Chen - JoVE (Journal of Visualized Experiments), 2018 - jove.com
Dorsal root ganglia (DRG) contain cell bodies of sensory neurons. This type of neuron is
pseudo-unipolar, with two axons that innervate peripheral tissues, such as skin, muscle and …
pseudo-unipolar, with two axons that innervate peripheral tissues, such as skin, muscle and …
Investigating SH-SY5Y neuroblastoma cell surfaceome as a model for neuronal-targeted novel therapeutic modalities
P Gangras, V Gelfanova, GD Williams… - International Journal of …, 2022 - mdpi.com
The SH-SY5Y neuroblastoma cells are a widely used in vitro model approximating neurons
for testing the target engagement of therapeutics designed for neurodegenerative diseases …
for testing the target engagement of therapeutics designed for neurodegenerative diseases …
Rapid Extraction and Identification of Maitotoxin and Ciguatoxin-Like Toxins from Caribbean and Pacific Gambierdiscus Using a New Functional Bioassay
Background Ciguatera is a circumtropical disease produced by polyether sodium channel
toxins (ciguatoxins) that enter the marine food chain and accumulate in otherwise edible …
toxins (ciguatoxins) that enter the marine food chain and accumulate in otherwise edible …
Modeling chemotherapy induced peripheral neuropathy (CIPN) in vitro: Prospects and limitations
Neuronal cell cultures have been used as an essential tool for studying pathomechanisms of
toxicity of chemotherapeutic drugs and to develop neuroprotective approaches. They offer …
toxicity of chemotherapeutic drugs and to develop neuroprotective approaches. They offer …