Protein kinases are dynamic molecular switches that have evolved to be only transiently
activated. Kinase activity is embedded within a conserved kinase core, which is typically …

Cellular signal transmission requires the dynamic formation of spatiotemporally controlled
molecular interactions. At the cell surface information is received by receptor complexes and …

Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult
population. Proteolytic turnover of tumour suppressors by the ubiquitin–proteasome system …

Drug addiction is a chronic, relapsing brain disorder. Multiple neural networks in the brain
including the reward system (eg, the mesocorticolimbic system), the anti-reward/stress …

Scaffolding proteins organize the information flow from activated G protein-coupled
receptors (GPCRs) to intracellular effector cascades both spatially and temporally. By this …

The aryl hydrocarbon receptor interacting protein (AIP) is a tumor-suppressor gene
underlying the pituitary adenoma predisposition. Thus far, the exact molecular mechanisms …

Genome-wide association studies as well as murine models have shown that the interleukin
23 receptor (IL23R) pathway plays a pivotal role in chronic inflammatory diseases such as …

Heterotrimeric G-proteins play crucial roles in growth, asexual development, and
pathogenicity of fungi. The regulator of G-protein signaling (RGS) proteins function as …

Post‐translational protein modifications, such as tyrosine phosphorylation, regulate protein–
protein interactions (PPI s) critical for signal processing and cellular phenotypes. We …

Background Bidirectional communication between presynaptic and postsynaptic
components contribute to the homeostasis of the synapse. In the neuromuscular synapse …