Calcium dynamics is central in cardiac physiology, as the key event leading to the excitation-
contraction coupling (ECC) and relaxation processes. The primary function of Ca2+ in the …

The therapeutic success of human stem cell-derived cardiomyocytes critically depends on
their ability to respond to and integrate with the surrounding electromechanical environment …

Overexpression of P2X7 receptors correlates with tumor growth and metastasis. Yet, release
of ATP is associated with immunogenic cancer cell death as well as inflammatory responses …

Na+ homeostasis is a key regulator of cardiac excitation and contraction. The cardiac
voltage-gated Na+ channel, NaV1. 5, critically controls cell excitability, and altered channel …

Sudden cardiac death (SCD) caused by ventricular arrhythmias is the leading cause of
mortality of cardiovascular disease. Mutation in TECRL, an endoplasmic reticulum protein …

Abstract Background Farnesoid X receptor (FXR) is a nuclear receptor that plays a critical
role in controlling cell apoptosis in diverse diseases. Previous studies have shown that …

Background The condition known as cachexia presents in most patients with malignant
tumours, leading to a poor quality of life and premature death. Although the cancer‐cachexia …

Background Istaroxime is an inhibitor of Na+/K+ ATPase with proven efficacy to increase
cardiac contractility and to accelerate relaxation attributable to a relief in phospholamban …

Previous studies by our group have demonstrated that the calcium imbalance in rat hepatic
stellate cells (HSCs) can induce endoplasmic reticulum stress (ERS) and promote cell …

Objectives: Sepsis is associated with cardiac contractile dysfunction attributed to alterations
in Ca 2+ handling. We examined the subcellular mechanisms involved in sarcoplasmic …