Taxanes in cancer treatment: Activity, chemoresistance and its overcoming
Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
Distinct functions of AKT isoforms in breast cancer: a comprehensive review
N Hinz, M Jücker - Cell Communication and Signaling, 2019 - Springer
Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
[HTML][HTML] Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention
NM Davis, M Sokolosky, K Stadelman, SL Abrams… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …
New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer
SX Yang, E Polley, S Lipkowitz - Cancer treatment reviews, 2016 - Elsevier
Abstract PI3K/AKT signaling pathway plays an important role in tumorigenesis and regulates
critical cellular functions including survival, proliferation and metabolism. PIK3CA mutations …
critical cellular functions including survival, proliferation and metabolism. PIK3CA mutations …
DNA damage, demethylation and anticancer activity of DNA methyltransferase (DNMT) inhibitors
ABA Laranjeira, MG Hollingshead, D Nguyen… - Scientific Reports, 2023 - nature.com
Role of DNA damage and demethylation on anticancer activity of DNA methyltransferase
inhibitors (DNMTi) remains undefined. We report the effects of DNMT1 gene …
inhibitors (DNMTi) remains undefined. We report the effects of DNMT1 gene …
Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells
YH Chen, SF Yang, CK Yang… - Molecular …, 2021 - spandidos-publications.com
Human cervical cancer is the fourth most common malignancy among women worldwide,
and it is expected to result in 460,000 deaths per year by 2040. Moreover, patients with …
and it is expected to result in 460,000 deaths per year by 2040. Moreover, patients with …
The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer
CA Castaneda, H Cortes-Funes, HL Gomez… - Cancer and Metastasis …, 2010 - Springer
The phosphatidyl inositol 3-kinase (PI3K)/Akt pathway mediates the effects of a variety of
extracellular signals in a number of cellular processes including cell growth, proliferation …
extracellular signals in a number of cellular processes including cell growth, proliferation …
Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis
JA McCubrey, SL Abrams, TL Fitzgerald… - Advances in biological …, 2015 - Elsevier
Abstract The EGFR/PI3K/PTEN/Akt/mTORC pathway plays prominent roles in malignant
transformation, prevention of apoptosis, drug resistance, cancer initiating cells (CICs) and …
transformation, prevention of apoptosis, drug resistance, cancer initiating cells (CICs) and …
CXCR2 promotes breast cancer metastasis and chemoresistance via suppression of AKT1 and activation of COX2
H Xu, F Lin, Z Wang, L Yang, J Meng, Z Ou, Z Shao… - Cancer letters, 2018 - Elsevier
Metastasis and chemoresistance are two major causes of breast cancer death. We show
here that the chemokine receptor CXCR2 was overexpressed in breast cancer cell lines and …
here that the chemokine receptor CXCR2 was overexpressed in breast cancer cell lines and …