Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning

G Buzsáki - Hippocampus, 2015 - Wiley Online Library
Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …

The kainic acid model of temporal lobe epilepsy

M Lévesque, M Avoli - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
The kainic acid model of temporal lobe epilepsy has greatly contributed to the
understanding of the molecular, cellular and pharmacological mechanisms underlying …

High‐frequency oscillations as a new biomarker in epilepsy

M Zijlmans, P Jiruska, R Zelmann… - Annals of …, 2012 - Wiley Online Library
The discovery that electroencephalography (EEG) contains useful information at frequencies
above the traditional 80Hz limit has had a profound impact on our understanding of brain …

Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration

M Lévesque, M Avoli, C Bernard - Journal of neuroscience methods, 2016 - Elsevier
In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to
develop new pharmacological treatments, in vivo animal models that present features …

Update on the mechanisms and roles of high‐frequency oscillations in seizures and epileptic disorders

P Jiruska, C Alvarado‐Rojas, CA Schevon, R Staba… - …, 2017 - Wiley Online Library
High‐frequency oscillations (HFO s) are a type of brain activity that is recorded from brain
regions capable of generating seizures. Because of the close association of HFO s with …

The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches

M Lévesque, G Biagini, M de Curtis… - Neuroscience & …, 2021 - Elsevier
Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …

Mechanisms of physiological and epileptic HFO generation

JGR Jefferys, LM De La Prida, F Wendling… - Progress in …, 2012 - Elsevier
High frequency oscillations (HFO) have a variety of characteristics: band-limited or broad-
band, transient burst-like phenomenon or steady-state. HFOs may be encountered under …

[HTML][HTML] Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection

NG Bazan - Molecular aspects of medicine, 2018 - Elsevier
The functional significance of the selective enrichment of the omega-3 essential fatty acid
docosahexaenoic acid (DHA; 22C and 6 double bonds) in cellular membrane phospholipids …

Noninvasive high-frequency oscillations riding spikes delineates epileptogenic sources

Z Cai, A Sohrabpour, H Jiang, S Ye… - Proceedings of the …, 2021 - National Acad Sciences
High-frequency oscillations (HFOs) are a promising biomarker for localizing epileptogenic
brain and guiding successful neurosurgery. However, the utility and translation of …

[HTML][HTML] Electrophysiological biomarkers of epilepsy

RJ Staba, M Stead, GA Worrell - Neurotherapeutics, 2014 - Elsevier
In patients being evaluated for epilepsy and in animal models of epilepsy,
electrophysiological recordings are carried to capture seizures to determine the existence of …