Mechanical cues in tumor microenvironment on chip
Mechanical cues from the tumor microenvironment (TME) can influence cell behaviors and
have been indicated to play a pivotal role in tumor initiation, progression, and metastasis …
have been indicated to play a pivotal role in tumor initiation, progression, and metastasis …
Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area
Rigidity sensing and durotaxis are thought to be important elements in wound healing,
tissue formation, and cancer treatment. It has been challenging, however, to study the …
tissue formation, and cancer treatment. It has been challenging, however, to study the …
[HTML][HTML] Capturing relevant extracellular matrices for investigating cell migration
P Keely, A Nain - F1000Research, 2015 - ncbi.nlm.nih.gov
Much progress in understanding cell migration has been determined by using classic two-
dimensional (2D) tissue culture platforms. However, increasingly, it is appreciated that …
dimensional (2D) tissue culture platforms. However, increasingly, it is appreciated that …
Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor
Scarring is a long-lasting problem in higher animals, and reductionist approaches could aid
in developing treatments. Here, we show that copolymerization of collagen I with …
in developing treatments. Here, we show that copolymerization of collagen I with …
Cyclic stretching-induced epithelial cell reorientation is driven by microtubule-modulated transverse extension during the relaxation phase
Many types of adherent cells are known to reorient upon uniaxial cyclic stretching
perpendicularly to the direction of stretching to facilitate such important events as wound …
perpendicularly to the direction of stretching to facilitate such important events as wound …
Polyacrylamide hydrogels prepared by varying water content during polymerization: Material characterization, reswelling ability, and aging resistance
V Penkavova, A Spalova, J Tomas… - Polymer Engineering & …, 2022 - Wiley Online Library
As easily fabricated, polyacrylamide (PAAm) hydrogels are widely used, especially in
medicine. Material properties of these crosslinked polymers are usually tuned by varying …
medicine. Material properties of these crosslinked polymers are usually tuned by varying …
Microdroplet formation in rounded flow-focusing junctions
Herein we report microfluidic droplet formation in flow-focusing geometries possessing
varying degrees of rounding. Rounding is incorporated in all four corners (symmetric) or only …
varying degrees of rounding. Rounding is incorporated in all four corners (symmetric) or only …
Cells on Hydrogels with Micron-Scaled Stiffness Patterns Demonstrate Local Stiffness Sensing
A Mgharbel, C Migdal, N Bouchonville, P Dupenloup… - Nanomaterials, 2022 - mdpi.com
Cell rigidity sensing—a basic cellular process allowing cells to adapt to mechanical cues—
involves cell capabilities exerting force on the extracellular environment. In vivo, cells are …
involves cell capabilities exerting force on the extracellular environment. In vivo, cells are …
On the Molecular Basis of Cellular Mechanobiology
Mechanical signals in biological tissues are generated within the extracellular matrix (ECM).
ECM is defined as the noncellular component of tissues and organs providing the cells with …
ECM is defined as the noncellular component of tissues and organs providing the cells with …
Manipulation of Durotaxis on a Matrix with Cell-scale Stiffness Heterogeneity
S Kidoaki - 2022 - books.rsc.org
Durotaxis, directional cell movement toward the stiffer region of the extracellular
environment, was first reported in 2000. 1 In early studies on durotaxis, the term …
environment, was first reported in 2000. 1 In early studies on durotaxis, the term …