Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during
embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds …

The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and
frequently co-opted during tumor development. Almost all colorectal cancers (CRC) …

Scope Exosomes, small vesicles participating in intercellular communication, have been
extensively studied recently; however, the role of edible plant derived exosomes in …

Dendritic cells (DCs) are the main professional antigen-presenting cells for induction of T-
cell adaptive responses. Cancer cells express tumor antigens, including neoantigens …

Despite recent advances, many cancers remain refractory to available immunotherapeutic
strategies. Emerging evidence indicates that the tolerization of local dendritic cells (DCs) …

Cell differentiation, proliferation, and death are vital for immune homeostasis. Wnt signaling
plays essential roles in processes across species. The roles of Wnt signaling proteins and …

Chronic inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are a
major health burden worldwide. Numerous conserved signaling pathways control tissue …

Wnt signaling is one of the important pathways to play a major role in various biological
processes, such as embryonic stem-cell development, tissue regeneration, cell …

The β-catenin signaling pathway has been demonstrated to promote the development of a
tolerogenic dendritic cell (DC) population capable of driving regulatory T-cell (Treg) …

The emergence of immunotherapy has profoundly changed the treatment model for triple-
negative breast cancer (TNBC). But the heterogeneity of this disease resulted in significant …