Pathogenicity and virulence of Aspergillus fumigatus
Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major
cause of morbidity and mortality globally. Compromised lung defences arising from …
cause of morbidity and mortality globally. Compromised lung defences arising from …
Fungal BGCs for production of secondary metabolites: main types, central roles in strain improvement, and regulation according to the piano principle
AA Zhgun - International Journal of Molecular Sciences, 2023 - mdpi.com
Filamentous fungi are one of the most important producers of secondary metabolites. Some
of them can have a toxic effect on the human body, leading to diseases. On the other hand …
of them can have a toxic effect on the human body, leading to diseases. On the other hand …
Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection
P Alves de Castro, C Figueiredo Pinzan… - Nature …, 2024 - nature.com
Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …
Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor CreA
Filamentous fungi of the genus Aspergillus are of particular interest for biotechnological
applications due to their natural capacity to secrete carbohydrate-active enzymes (CAZy) …
applications due to their natural capacity to secrete carbohydrate-active enzymes (CAZy) …
Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities
EM Huber - ChemBioChem, 2022 - Wiley Online Library
Epipolythiodioxopiperazines (ETPs) are fungal secondary metabolites that share a 2, 5‐
diketopiperazine scaffold built from two amino acids and bridged by a sulfide moiety …
diketopiperazine scaffold built from two amino acids and bridged by a sulfide moiety …
Gliotoxin, an Immunosuppressive Fungal Metabolite, Primes Plant Immunity: Evidence from Trichoderma virens-Tomato Interaction
R Zaid, R Koren, E Kligun, R Gupta… - MBio, 2022 - Am Soc Microbiol
Beneficial interaction of members of the fungal genus Trichoderma with plant roots primes
the plant immune system, promoting systemic resistance to pathogen infection. Some strains …
the plant immune system, promoting systemic resistance to pathogen infection. Some strains …
The toxic mechanism of gliotoxins and biosynthetic strategies for toxicity prevention
W Ye, T Liu, W Zhang, W Zhang - International Journal of Molecular …, 2021 - mdpi.com
Gliotoxin is a kind of epipolythiodioxopiperazine derived from different fungi that is
characterized by a disulfide bridge. Gliotoxins can be biosynthesized by a gli gene cluster …
characterized by a disulfide bridge. Gliotoxins can be biosynthesized by a gli gene cluster …
Presence, Mode of Action, and Application of Pathway Specific Transcription Factors in Aspergillus Biosynthetic Gene Clusters
Fungal secondary metabolites are renowned toxins as well as valuable sources of
antibiotics, cholesterol-lowering drugs, and immunosuppressants; hence, great efforts were …
antibiotics, cholesterol-lowering drugs, and immunosuppressants; hence, great efforts were …
Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin
Aspergillus fumigatus is the main causative agent of invasive pulmonary aspergillosis (IPA),
a severe disease that affects immunosuppressed patients worldwide. The fungistatic drug …
a severe disease that affects immunosuppressed patients worldwide. The fungistatic drug …
Fungal secondary metabolism is governed by an RNA-binding protein CsdA/RsdA complex
Production of secondary metabolites is controlled by a complicated regulatory network in
eukaryotic cells. Several layers of regulators are involved in this process, ranging from …
eukaryotic cells. Several layers of regulators are involved in this process, ranging from …