Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major
cause of morbidity and mortality globally. Compromised lung defences arising from …

Filamentous fungi are one of the most important producers of secondary metabolites. Some
of them can have a toxic effect on the human body, leading to diseases. On the other hand …

Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …

Filamentous fungi of the genus Aspergillus are of particular interest for biotechnological
applications due to their natural capacity to secrete carbohydrate-active enzymes (CAZy) …

Epipolythiodioxopiperazines (ETPs) are fungal secondary metabolites that share a 2, 5‐
diketopiperazine scaffold built from two amino acids and bridged by a sulfide moiety …

Beneficial interaction of members of the fungal genus Trichoderma with plant roots primes
the plant immune system, promoting systemic resistance to pathogen infection. Some strains …

Gliotoxin is a kind of epipolythiodioxopiperazine derived from different fungi that is
characterized by a disulfide bridge. Gliotoxins can be biosynthesized by a gli gene cluster …

Fungal secondary metabolites are renowned toxins as well as valuable sources of
antibiotics, cholesterol-lowering drugs, and immunosuppressants; hence, great efforts were …

Aspergillus fumigatus is the main causative agent of invasive pulmonary aspergillosis (IPA),
a severe disease that affects immunosuppressed patients worldwide. The fungistatic drug …

Production of secondary metabolites is controlled by a complicated regulatory network in
eukaryotic cells. Several layers of regulators are involved in this process, ranging from …