The cloning of genes encoding mammalian DNA binding transcription factors for RNA
polymerase II has provided the opportunity to analyze the structure and function of these …

NF-IL6 was originally identified as a DNA-binding protein responsible for IL-1-stimulated IL-
6 induction. Direct cloning of NF-IL6 revealed its homology with C/EBP. C/EBP is expressed …

Hypersensitive site 2 located in the beta-globin locus control region confers high levels of
expression to the genes of the beta-globin cluster. A tandem repeat of the consensus …

The myc protooncogene family has been implicated in cell proliferation, differentiation, and
neoplasia, but its mechanism of function at the molecular level is unknown. The carboxyl …

When activated, NF-κB, a ubiquitous transcription factor, binds DNA as a heterodimeric
complex composed of members of the Rel/NF-κB family of polypeptides. Because of its …

We demonstrated that the GCC box, which is an 11-bp sequence (TAAGAGCCGCC)
conserved in the 5'upstream region of ethylene-inducible pathogenesis-related protein …

In Arabidopsis, the induction of a dehydration-responsive gene, rd22, is mediated by
abscisic acid (ABA) and requires protein biosynthesis for ABA-dependent gene expression …

Two cDNAs were isolated whose dimerized products bind specifically to a DNA sequence,
KEY, located in the immunoglobulin kappa chain enhancer. Both cDNAs share a region of …

Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives,
is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory …

Human immunodeficiency virus type 1 (HIV-1) gene expression is modulated by both viral
and cellular factors. A regulatory element in the HIV-1 long terminal repeat known as TAR …