Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various
cellular processes and is aberrantly activated in cancers, contributing to the occurrence and …

Since its inception in 2000, metronomic chemotherapy has undergone major advances as
an antiangiogenic therapy. The discovery of the pro-immune properties of chemotherapy …

The administration of chemotherapy at reduced doses given at regular, frequent time
intervals, termed 'metronomic'chemotherapy, presents an alternative to standard maximal …

Simple Summary The present article reviews the state of the art of metronomic
chemotherapy use to treat the principal types of cancers, namely breast, non-small cell lung …

Metronomic chemotherapy, continuous and dose‐dense administration of chemotherapeutic
drugs with lowered doses, is being evaluated for substituting, augmenting, or appending …

Metronomic dosing of chemotherapy—defined as frequent administration at lower doses—
has been shown to be more efficacious than maximum tolerated dose treatment in …

Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense
desmoplastic stroma that limits the delivery of anticancer agents. VCN-01 is an oncolytic …

Nanomedicine offered hope for improving the treatment of cancer but the survival benefits of
the clinically approved nanomedicines are modest in many cases when compared to …

Simple Summary Metronomic chemotherapy, a continuous administration of a lowered dose
of drugs without long breaks, is currently considered an alternative approach for the …

Physiologic barriers to drug delivery and selection for drug resistance limit survival
outcomes in cancer patients. In this study, we present preclinical evidence that a …