Copy number variations (CNVs) which include deletions, duplications, inversions,
translocations, and other forms of chromosomal re-arrangements are common to human …

Abstract The Multiple Endocrine Neoplasia I (MEN1) locus encodes the protein MENIN,
which functions as a tumor suppressor protein in neuroendocrine tissues. Gastrinomas are …

The delayed diagnosis of pancreatic cancer has resulted in rising mortality rate and low
survival rate that can be circumvented using potent theranostics biomarkers. The treatment …

Background Breast cancer is a multifactorial disease which involves number of molecular
factors that are critically involved in proliferation of breast cancer cells. MEN1 gene that is …

Menin/MEN1 is a scaffold protein that participates in proliferation, regulation of gene
transcription, DNA damage repair, and signal transduction. In hematological malignancies …

Ovarian cancer is a common cause of death among women worldwide. The current
diagnostic and prognostic procedures available for the treatment of ovarian cancer are …

Purpose Patients with multiple endocrine neoplasia type 1 (MEN1) are predisposed to
develop duodenopancreatic neuroendocrine tumors (dpNETs), and metastatic dpNET is the …

Acromegaly is a rare endocrine disorder characterized by the excessive production of
growth hormone (GH) in adulthood. Currently, it is understood that certain pituitary …

Human menin is a nuclear protein that participates in many cellular processes, as
transcriptional regulation, DNA damage repair, cell signaling, cell division, proliferation, and …

Pancreatic cancer (PC) is an aggressive disease characterized by high mortality. Diagnosis
at advanced stage, resistance, and recurrence are major hurdles for PC therapy and …