Invention of MK-8262, a cholesteryl ester transfer protein (CETP) inhibitor backup to anacetrapib with best-in-class properties
Cholesteryl ester transfer protein (CETP) represents one of the key regulators of the
homeostasis of lipid particles, including high-density lipoprotein (HDL) and low-density …
homeostasis of lipid particles, including high-density lipoprotein (HDL) and low-density …
New approach methodologies to confirm developmental toxicity of pharmaceuticals based on weight of evidence
The aim of embryo-fetal developmental toxicity assessments for pharmaceuticals is to inform
potential risk of adverse pregnancy outcome, which has traditionally relied on studies in …
potential risk of adverse pregnancy outcome, which has traditionally relied on studies in …
Analysis of exposure margins in developmental toxicity studies for detection of human teratogens
PA Andrews, D Blanset, PL Costa, M Green… - Regulatory Toxicology …, 2019 - Elsevier
Abstract The draft Step 2 ICH S5 (R3) guideline includes an exposure-based endpoint as an
option for selecting the high-dose in reproductive and developmental toxicity studies. To …
option for selecting the high-dose in reproductive and developmental toxicity studies. To …
[PDF][PDF] Embryotoxicity and teratogenicity of tamarind (Tamarindus indica L.) pulp extract using zebrafish (Danio rerio) embryo toxicity assay.
IC Lobitaña, RME Virtudazo, AMP Delfin, JNB Apura… - 2020 - researchgate.net
Tamarind is an economically important fruit, widely used in traditional medicine due to its
therapeutic properties. However, its bioactive compounds raise an increased precaution on …
therapeutic properties. However, its bioactive compounds raise an increased precaution on …
Alternative methods used to assess potential embryo-fetal developmental risk of pharmaceuticals
ML Green, JT Gamse, KC Brannen - Developmental and Reproductive …, 2017 - Springer
Alternative developmental toxicity assays are used by pharmaceutical companies to detect
the teratogenic potential of human drugs. These methods are intended to reduce, refine, or …
the teratogenic potential of human drugs. These methods are intended to reduce, refine, or …