Protein solid-state NMR has evolved dramatically over the last two decades, with the
development of new hardware and sample preparation methodologies. This technique is …

Multispecific biologics are an emerging class of drugs, in which antibodies and/or proteins
designed to bind pharmacological targets are covalently linked or expressed as fusion …

Candidate drugs rationally designed in vitro often fail due to low efficacy in vivo caused by
low tissue availability or because of unwanted side effects. To overcome the limitations of in …

Structure-based drug development suffers from high attrition rates due to the poor activity of
lead compounds in cellular and animal models caused by low cell penetrance, off-target …

The heterogeneous composition of vaccine formulations and the relatively low concentration
make the characterization of the protein antigens extremely challenging. Aluminum …

Developing biological formulations to maintain the chemical and structural integrity of
therapeutic antibodies remains a significant challenge. Monoclonal antibody (mAb) …

Paramagnetic NMR data can be profitably incorporated in structural refinement protocols of
metalloproteins or metal-substituted proteins, mostly as distance or angle restraints …

Nuclear magnetic resonance (NMR) is an effective, commonly used experimental approach
to screen small organic molecules against a protein target. A very popular method consists …

Many proteins naturally carry metal centers, with a large share of them being in the active
sites of several enzymes. Paramagnetic effects are a powerful source of structural …

Cationic antimicrobial peptides (AMPs) are essential components of the innate immune
system. They have attracted interest as novel compounds with the potential to treat infections …