Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Oxidative stress and antioxidants in neurodegenerative disorders

EO Olufunmilayo, MB Gerke-Duncan, RMD Holsinger - Antioxidants, 2023 - mdpi.com
Neurodegenerative disorders constitute a substantial proportion of neurological diseases
with significant public health importance. The pathophysiology of neurodegenerative …

Glutathione in the Brain

K Aoyama - International journal of molecular sciences, 2021 - mdpi.com
Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the
antioxidant defense system and the maintenance of redox homeostasis in neurons. GSH …

[HTML][HTML] Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases

Y Song, J Liu, K Zhao, L Gao, J Zhao - Cell metabolism, 2021 - cell.com
High levels of cholesterol are generally considered to be associated with atherosclerosis. In
the past two decades, however, a number of studies have shown that excess cholesterol …

Changes in glutathione content in liver diseases: an update

M Vairetti, LG Di Pasqua, M Cagna, P Richelmi… - Antioxidants, 2021 - mdpi.com
Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important
thiol reducing agent involved in the modulation of redox processes. It has also been …

Reactive oxygen species: Role in carcinogenesis, cancer cell signaling and tumor progression

FL Sarmiento-Salinas, A Perez-Gonzalez… - Life Sciences, 2021 - Elsevier
Cancer is one of the major causes of death in the world and its global burden is expected to
continue increasing. In several types of cancers, reactive oxygen species (ROS) have been …

Mitochondrial management of reactive oxygen species

G Napolitano, G Fasciolo, P Venditti - Antioxidants, 2021 - mdpi.com
Mitochondria in aerobic eukaryotic cells are both the site of energy production and the
formation of harmful species, such as radicals and other reactive oxygen species, known as …

Antioxidants in Alzheimer's disease: Current therapeutic significance and future prospects

P Pritam, R Deka, A Bhardwaj, R Srivastava, D Kumar… - Biology, 2022 - mdpi.com
Simple Summary Alzheimer's disease (AD) is the most common neurodegenerative disease,
intensifying impairments in cognition, behavior, and memory. Histopathological AD …

[HTML][HTML] Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation

CA Labarrere, GS Kassab - Frontiers in Nutrition, 2022 - frontiersin.org
Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

Redefining oxidative stress in Alzheimer's disease: Targeting platelet reactive oxygen species for novel therapeutic options

SK Beura, R Dhapola, AR Panigrahi, P Yadav… - Life Sciences, 2022 - Elsevier
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is considered
one of the most common causes of dementia worldwide, accounting for about 80% of all …