S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2+ binding
proteins belonging to the S100 family. They often exist in the form of heterodimer, while …

The composition and organisation of the extracellular matrix (ECM), particularly the
pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the …

Understanding the causality of the post-traumatic osteoarthritis (PTOA) disease process of
the knee joint is important for diagnosing early disease and developing new and effective …

Microplastics (MPs) have been detected in various human tissues, including the liver,
placenta, and blood. However, studies about MPs in the human locomotor system are …

Objective Osteoarthritis (OA) exposes all joint tissues to physiologic stresses, increasing the
need to clear apoptotic cells from tissues, including the synovium. We undertook this study to …

Osteoarthritis (OA) is a multifactorial disease in which genetics, aging, obesity, and trauma
are well-known risk factors. It is the most prevalent joint disease and the largest disability …

The prevalence of Osteoarthritis (OA) is increasing because of the progressive aging and
unhealthy lifestyle. These risk factors trigger OA by removing constraints that keep the tightly …

Knee osteoarthritis (KOA), the highly prevalent degenerative disease affecting the joint,
perpetually devastates the health of the elderly. Of various mechanisms known to participate …

Osteoarthritis (OA) is a chronic inflammatory disease where pro-inflammatory cytokines,
damage-associated molecular patterns (DAMPs), and macrophages play a crucial role …

Objective The alarmin HMGB1 is an endogenous molecule that is released into the
extracellular space upon trauma or cell activation. Extracellular HMGB1 initiates innate …