In recent years, there has been an explosion of interest in how fibroblasts initiate, sustain,
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …

Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

Epithelial-to-mesenchymal transition (EMT) is a reversible process, in which epithelial cells
lose their epithelial traits and acquire a mesenchymal phenotype. This transformation has …

The pulmonary extracellular matrix (ECM) is a macromolecular structure that provides
mechanical support, stability and elastic recoil for different pulmonary cells including the …

Inflammatory factors have been considered to contribute to keratoconus (KC) pathogenesis.
This study aims to determine the immune cells subsets and soluble inflammatory factor …

Idiopathic pulmonary fibrosis (IPF) is a dramatic disease without cure. The US Food and
Drug Administration–approved drugs, pirfenidone and nintedanib, only slow disease …

The lung extracellular matrix (ECM) is a complex and dynamic mixture of fibrous proteins
(collagen, elastin), glycoproteins (fibronectin, laminin), glycosaminoglycans (heparin …

As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental
processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) …

Background Type 2 innate lymphoid cells (ILC2s) are relevant players in type 2 asthma.
They initiate eosinophil infiltration and airway hyperreactivity (AHR) through cytokine …