Kinase activation and phosphorylation cascades are key to initiate immune cell activation in
response to recognition of antigen and sensing of microbial danger. However, for balanced …

Tumor-associated macrophages (TAMs) play a significant role in at least two key processes
underlying neoplastic progression: angiogenesis and immune surveillance. TAMs …

The cellular origin of hepatocellular carcinomas (HCC) and the role of Notch1 signalling in
HCC initiation are controversial. Herein, we establish Notch1 as a regulator of HCC …

Protein tyrosine kinases (PTK), discovered in the 1970s, have been considered master
regulators of biological processes with high clinical significance as targets for human …

Abstract Mancozeb (MCZ), a broad-spectrum fungicide, has been widely used in crops
(tomatoes and potatoes) in the past few decades, resulting in its bioaccumulation in the food …

Cancer stem cells (CSCs) actively reprogram their tumor microenvironment (TME) to sustain
a supportive niche, which may have a dramatic impact on prognosis and immunotherapy …

Abstract Aim Dual Specificity Phosphatase 3 (DUSP3) regulates the innate immune
response, with a putative role in angiogenesis. Modulating inflammation and perfusion …

Cutaneous melanoma circulating tumour cells (CTCs) are phenotypically and molecularly
heterogeneous. We profiled the gene expression of CTC subpopulations immunomagnetic …

The regulation of protein kinases by dephosphorylation is a key mechanism that defines the
activity of immune cells. A balanced process of the phosphorylation/dephosphorylation of …

Phosphatases play an important role in cellular signaling and are often found dysregulated
in cancers including glioblastoma (GBM). A comprehensive bioinformatics analysis of …