Recent expansions of novel strategies towards the drug targeting into the brain

A Alexander, M Agrawal, A Uddin… - International journal …, 2019 - Taylor & Francis
The treatment of central nervous system (CNS) disorders always remains a challenge for the
researchers. The presence of various physiological barriers, primarily the blood–brain …

Efflux pump mediated antimicrobial resistance by staphylococci in health-related environments: challenges and the quest for inhibition

A Dashtbani-Roozbehani, MH Brown - Antibiotics, 2021 - mdpi.com
The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major
health threat worldwide due to significant morbidity and mortality resulting from their …

Guanidinium export is the primal function of SMR family transporters

AA Kermani, CB Macdonald… - Proceedings of the …, 2018 - National Acad Sciences
The small multidrug resistance (SMR) family of membrane proteins is prominent because of
its rare dual topology architecture, simplicity, and small size. Its best studied member, EmrE …

Biocide selective TolC-independent efflux pumps in Enterobacteriaceae

CJ Slipski, GG Zhanel, DC Bay - The Journal of membrane biology, 2018 - Springer
Bacterial resistance to biocides used as antiseptics, dyes, and disinfectants is a growing
concern in food preparation, agricultural, consumer manufacturing, and health care …

Characterization of Proteobacterial Plasmid Integron-Encoded qac Efflux Pump Sequence Diversity and Quaternary Ammonium Compound Antiseptic Selection in …

CJ Slipski, TR Jamieson-Datzkiw… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Qac efflux pumps from proteobacterial multidrug-resistant plasmids are integron encoded
and confer resistance to quaternary ammonium compound (QAC) antiseptics; however …

Modern anti-tuberculosis drugs and their classification. Part I: first-line drugs

LA Kayukova, EA Berikova - Pharmaceutical Chemistry Journal, 2020 - Springer
The historical classification (1993) of anti-tuberculosis drugs included three (I-III) lines that
were subdivided into five groups (2006). The duration of treatment of drug-sensitive (DS) …

Comparative genomics of Stutzerimonas balearica (Pseudomonas balearica): diversity, habitats, and biodegradation of aromatic compounds

F Salvà-Serra, D Pérez-Pantoja, RA Donoso… - Frontiers in …, 2023 - frontiersin.org
Stutzerimonas balearica (Pseudomonas balearica) has been found principally in oil-polluted
environments. The capability of S. balearica to thrive from the degradation of pollutant …

Riboswitch-associated guanidinium-selective efflux pumps frequently transmitted on proteobacterial plasmids increase Escherichia coli biofilm tolerance to …

CJ Slipski, TR Jamieson, GG Zhanel… - Journal of …, 2020 - Am Soc Microbiol
Members of the small multidrug resistance (SMR) efflux pump family known as SugE
(recently renamed Gdx) are known for their narrow substrate selectivity to small guanidinium …

Role of efflux in enhancing butanol tolerance of bacteria

M Vasylkivska, P Patakova - Journal of Biotechnology, 2020 - Elsevier
N-butanol, a valued solvent and potential fuel extender, could possibly be produced by
fermentation using either native producers, ie solventogenic Clostridia, or engineered …

Functional Role of YnfA, an Efflux Transporter in Resistance to Antimicrobial Agents in Shigella flexneri

T Sen, NK Verma - Antimicrobial Agents and Chemotherapy, 2022 - Am Soc Microbiol
Shigella flexneri has become a significant public health concern accounting for the majority
of shigellosis cases worldwide. Even though a multitude of efforts is being made into the …