Inhibiting glycogen synthase kinase-3 (GSK-3) activity via pharmacological intervention has
become an important strategy for treating neurodegenerative and psychiatric disorders. The …

Covering: 2009. Previous review: Nat. Prod. Rep., 2010, 27, 165 This review covers the
literature published in 2009 for marine natural products, with 857 citations (588 for the …

Most kinase inhibitors are designed to bind to highly homologous ATP-binding sites, which
leads to promiscuity and possible off-target effects. Allostery is an alternative approach to …

Glycogen synthase kinase 3β (GSK-3β) is widely recognised as a relevant player in the
pathogenesis of several highly prevalent disorders such as Alzheimer's disease, mood …

Facile and versatile access to highly functionalized tetronic acids has been successfully
achieved through the reaction of conjugated ynones with carbon dioxide. In the presence of …

Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration
for marine biotechnology, particularly in drug discovery programs and biomaterials …

The Krapcho reaction involves esters with α‐electron‐withdrawing substituents such as
malonates, β‐keto esters, and α‐cyano esters, which undergo dealkoxycarbonylation on …

During the last decades the interest towards natural products containing the tetronic acid
moiety augmented significantly, due to their challenging structures and to the wide range of …

Corn silk (Stigma Maydis) has been utilized as an important herb against obesity by
Chinese, Korean, and Native Americans, but its phytochemicals and mechanisms (s) against …

This useful reference focuses on the currently available toolbox of bio-catalysed reductions
of C= O, C= C and formal C= N bonds to show which transformations can be reliably used in …