As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of
cellular processes, including those involving vascular cells. This brief review summarizes …

Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …

The small bilobal calcium regulatory protein calmodulin (CaM) activates numerous target
enzymes in response to transient changes in intracellular calcium concentrations. Binding of …

Proteins are vital for basically every known organism. Therefore the investigation of their
structure, the development of a deeper understanding of protein–protein interactions and the …

Proteins in nature fold into native conformations in which combinations of peripherally
projected aliphatic, aromatic and ionic functionalities direct a wide range of properties. α …

The actin cytoskeleton is critical for form and function of vascular cells, serving mechanical,
organizational and signaling roles. Because many cytoskeletal proteins are sensitive to …

Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a
critical second messenger involved in numerous biological activities through extensive …

Research in bioelectronics is highly interdisciplinary, with many new developments being
based on techniques from across the physical and life sciences. Advances in our …

Biophysical stimuli presented to cells via microenvironmental properties (eg, alignment and
stiffness) or external forces have a significant impact on cell function and behavior. Recently …

Here we report the structure of the widely utilized calmodulin (CaM)-dependent protein
kinase II (CaMKII) inhibitor KN93 bound to the Ca 2+-sensing protein CaM. KN93 is widely …