Cancer is one of the major causes of mortality worldwide, therefore it is considered a major
health concern. Breast cancer is the most frequent type of cancer which affects women on a …

Abstract The Ubiquitin-Proteasome System (UPS) is an important regulator of cell signaling
and proteostasis, which are essential to a variety of cellular processes. The UPS is disrupted …

Nuclear hormone receptors (NRs) are ligand-binding transcription factors that are widely
targeted therapeutically. Agonist binding triggers NR activation and subsequent degradation …

Chemical toxicity can arise from disruption of specific biomolecular functions or through
more generalized cell stress and cytotoxicity-mediated processes. Here, responses of 1060 …

Background: The up-regulation of PD-L1 is recognized as an adaption of cancer cells to
evade immune surveillance and attack. However, the intrinsic mechanisms of the induction …

Pancreatic cancer is one of the most fatal cancers in humans. While it thrives in a state of
malnutrition, the mechanism by which pancreatic cancer cells adapt to metabolic stress …

Patients with triple-negative breast cancers (TNBC) are at high risk for recurrence and
metastasis at an early time despite standard treatment, underscoring the need for novel …

Background Estrogen plays a critical role in breast cancer (BC) progression through
estrogen receptor (ER)-mediated gene regulation. Emerging studies suggest that the …

The exponential development of highly advanced scientific and medical research
technologies throughout the past 30 years has arrived to the point where the high number of …

We recently discovered that steroid receptor coactivators (SRCs) SRCs-1, 2 and 3, are
abundantly expressed in cardiac fibroblasts (CFs) and their activation with the SRC small …