Biosynthesis and therapeutic implications of iridoid glycosides from Picrorhiza genus: the road ahead

V Kumar, RS Chauhan, C Tandon - Journal of Plant Biochemistry and …, 2017 - Springer
Picrorhiza genus is emerging as an important paradigm for herbal drug formulations due to
its versatile iridoid glycosides exhibition and robustness in the treatment of diverse infections …

Growth Kinetics, Metabolites Production and Expression Profiling of Picrosides Biosynthetic Pathway Genes in Friable Callus Culture of Picrorhiza kurroa Royle ex …

M Partap, P Kumar, Ashrita, P Kumar, D Kumar… - Applied Biochemistry …, 2020 - Springer
The rising demand for picrosides commercially and over-exploitation of Picrorhiza kurroa
from natural habitat has to initiate alternative strategies for sustainable production of …

Exogenous feeding of immediate precursors reveals synergistic effect on picroside-I biosynthesis in shoot cultures of Picrorhiza kurroa Royle ex Benth

V Kumar, N Sharma, H Sood, RS Chauhan - Scientific Reports, 2016 - nature.com
In the current study, we asked how the supply of immediate biosynthetic precursors ie
cinnamic acid (CA) and catalpol (CAT) influences the synthesis of picroside-I (PI) in shoot …

Modular design of picroside-II biosynthesis deciphered through NGS transcriptomes and metabolic intermediates analysis in naturally variant chemotypes of a …

V Kumar, A Bansal, RS Chauhan - Frontiers in Plant Science, 2017 - frontiersin.org
Picroside-II (P-II), an iridoid glycoside, is used as an active ingredient of various commercial
herbal formulations available for the treatment of liver ailments. Despite this, the knowledge …

Complexity of gene paralogues resolved in biosynthetic pathway of hepatoprotective iridoid glycosides in a medicinal herb, Picrorhiza kurroa through differential NGS …

A Kharb, RS Chauhan - Molecular Genetics and Genomics, 2021 - Springer
Picrorhiza kurroa is a medicinal herb with diverse pharmacological applications due to the
presence of iridoid glycosides, picroside-I (PI), and picroside-II (P-II), among others. Any …

Comparative transcriptome analysis in different tissues of a medicinal herb, Picrorhiza kurroa pinpoints transcription factors regulating picrosides biosynthesis

I Vashisht, T Pal, H Sood, RS Chauhan - Molecular biology reports, 2016 - Springer
Transcriptional regulation of picrosides biosynthesis, the iridoid glycosides of an
endangered medicinal herb, Picrorhiza kurroa, is completely unknown. P. kurroa plants …

Molecular dissection of pathway components unravel atisine biosynthesis in a non-toxic Aconitum species, A. heterophyllum Wall

V Kumar, N Malhotra, T Pal, RS Chauhan - 3 Biotech, 2016 - Springer
Aconitum heterophyllum is an important component for various herbal drug formulations due
to the occurrence of non-toxic aconites including marker compound, atisine. Despite huge …

Growth dynamics and differential accumulation of picrosides and its precursor metabolites in callus cell lines of Picrorhiza kurroa with distinct anti-steatotic potential

M Partap, J Chhimwal, P Kumar, D Kumar… - Process …, 2022 - Elsevier
Picrorhiza kurroa is an industrially important Himalayan medicinal herb and is well known
for its therapeutic potent picrosides compounds. The limited availability and medicinal usage …

Modulation of Picroside-I Biosynthesis in Grown Elicited Shoots of Picrorhiza kurroa In Vitro

N Sharma, V Kumar, RS Chauhan, H Sood - Journal of Plant Growth …, 2016 - Springer
Elicitors are considered as biostimulants for growth improvement and enhancement of
secondary metabolite content. To date, only seaweed extract (SWE) powder has been …

[HTML][HTML] Transcriptome profiling reveal key hub genes in co-expression networks involved in Iridoid glycosides biosynthetic machinery in Picrorhiza kurroa

A Sharma, D Bhattacharyya, S Sharma, RS Chauhan - Genomics, 2021 - Elsevier
Picrorhiza kurroa is a medicinal herb rich in hepatoprotective iridoid glycosides, picroside-I
(PI) and picroside-II (P-II). The biosynthetic machinery of picrosides is poorly understood …