A wide range of life-threatening conditions with complicated pathogenesis involves
neurovascular disorders encompassing Neurovascular unit (NVU) damage. The …

Chronic musculoskeletal pain is among the most highly prevalent diseases worldwide.
Managing patients with chronic pain remains very challenging because current imaging …

Opioids regulate various physiological and pathophysiological functions, including cell
proliferation, immune function, obesity, and neurodegenerative disorders. They have been …

Inflammation is linked with chronic pain but the extent to which this relationship is associated
with biopsychosocial factors is not known. We investigated relationships between blood C …

Background Crohn's disease-(CD) pathogenesis is still unknown and chronic pain is a
frequent symptom in CD-patients. Identifying novel therapeutic targets and predisposing …

Purpose Causal mechanisms underlying systemic inflammation in spinal & widespread pain
remain an intractable experimental challenge. Here we examined whether:(i) associations …

Inflammation during the perioperative period of joint arthroplasty is a critical aspect of patient
outcomes, influencing both the pathophysiology of pain and the healing process. This …

Novel AT2R Antagonists for Treating Chronic Pain Page 1 Novel AT2R Antagonists for
Treating Chronic Pain Ram W. Sabnis* Cite This: https://doi.org/10.1021/acsmedchemlett.4c00046 …

Chronic pain is a significant public health issue. Current treatments have limited efficacy and
significant side effects, warranting research on alternative strategies for pain management …

Introduction: Fentanyl and non-pharmaceutical fentanyl use have been the leading causes
of opioid-induced death worldwide. Being 50 times stronger than heroin and 100 times …