Antiviral drug discovery: preparing for the next pandemic

CS Adamson, K Chibale, RJM Goss… - Chemical Society …, 2021 - pubs.rsc.org
Clinically approved antiviral drugs are currently available for only 10 of the more than 220
viruses known to infect humans. The SARS-CoV-2 outbreak has exposed the critical need …

RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic

L Tian, T Qiang, C Liang, X Ren, M Jia, J Zhang… - European journal of …, 2021 - Elsevier
The widespread nature of several viruses is greatly credited to their rapidly altering RNA
genomes that enable the infection to persist despite challenges presented by host cells …

Lessons in self-defence: inhibition of virus entry by intrinsic immunity

S Majdoul, AA Compton - Nature Reviews Immunology, 2022 - nature.com
Virus entry, consisting of attachment to and penetration into the host target cell, is the first
step of the virus life cycle and is a critical 'do or die'event that governs virus emergence in …

[HTML][HTML] Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives

L Mei, S Zhu, W Yin, C Chen, G Nie, Z Gu, Y Zhao - Theranostics, 2020 - ncbi.nlm.nih.gov
The marked augment of drug-resistance to traditional antibiotics underlines the crying need
for novel replaceable antibacterials. Research advances have revealed the considerable …

Emerging viruses without borders: the Wuhan coronavirus

SL Liu, L Saif - Viruses, 2020 - mdpi.com
The recently emerged coronavirus in Wuhan, China has claimed at least six lives as of
January 22 and infected hundreds if not thousands of individuals. The situation has drawn …

The COVID 19 novel coronavirus pandemic 2020: seaweeds to the rescue? Why does substantial, supporting research about the antiviral properties of seaweed …

L Pereira, AT Critchley - Journal of Applied Phycology, 2020 - Springer
Presently, there is lack of a vaccine that would lead to immunization against the virus COVID-
19, but here are some of the characteristics that various seaweeds have and which may …

Role of selenium in viral infections with a major focus on SARS-CoV-2

SS Martinez, Y Huang, L Acuna, E Laverde… - International Journal of …, 2021 - mdpi.com
Viral infections have afflicted human health and despite great advancements in scientific
knowledge and technologies, continue to affect our society today. The current coronavirus …

The Pacific oyster mortality syndrome, a polymicrobial and multifactorial disease: state of knowledge and future directions

B Petton, D Destoumieux-Garzón, F Pernet… - Frontiers in …, 2021 - frontiersin.org
The Pacific oyster (Crassostreae gigas) has been introduced from Asia to numerous
countries around the world during the 20th century. C. gigas is the main oyster species …

Why is Pakistan vulnerable to COVID‐19 associated morbidity and mortality? A scoping review

M Atif, I Malik - The International journal of health planning and …, 2020 - Wiley Online Library
The scoping review was undertaken to outline the vulnerabilities of Pakistan's public health
and healthcare system, which put the population at increased risk of coronavirus disease …

Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis

D Reynolds, M Huesemann, S Edmundson, A Sims… - Algal Research, 2021 - Elsevier
Viruses are abiotic obligate parasites utilizing complex mechanisms to hijack cellular
machinery and reproduce, causing multiple harmful effects in the process. Viruses represent …