Autophagy is a major protein turnover pathway by which cellular components are delivered
into the lysosomes for degradation and recycling. This intracellular process is able to …

Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Abstract Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the
endoplasmic reticulum, where they impact Ca2+ dynamics by controlling IP3 receptor (IP3R) …

In addition to their role in providing cellular energy, mitochondria fulfill a key function in
cellular calcium management. The present review provides an integrative view of cellular …

Calcium ions (Ca2+) play a complex role in orchestrating diverse cellular processes,
including cell death and survival. To trigger signaling cascades, intracellular Ca2+ is …

Ageing can occur at different rates, but what controls this variable rate is unknown. Here I
have developed a hypothesis that vitamin D may act to control the rate of ageing. The basis …

Inter-organellar communication often takes the form of Ca2+ signals. These Ca2+ signals
originate from the endoplasmic reticulum (ER) and regulate different cellular processes like …

Organelles form tight connections through membrane contact sites, thereby cooperating to
regulate homeostasis and cell function. Among them, the contact between endoplasmic …

Alzheimer's disease (AD) is a neurodegenerative disorder with progressive memory loss
resulting in dementia. Amyloid-beta (Aβ) peptides play a critical role in the pathogenesis of …