To bridge the gap between organ demand and supply, xenotransplantation has long been
considered as a realistic option for end-stage organ failure. Early this year this promise …

The first genetically modified large animals were developed in 1985 by microinjection to
increase the growth of agricultural livestock such as pigs. Since then, it has been a difficult …

Background Cell surface carbohydrate antigens play a major role in the rejection of porcine
xenografts. The most important for human recipients are α‐1, 3 Gal (Galactose‐alpha‐1, 3 …

Genetically modified animals continue to provide important insights into the molecular basis
of health and disease. Research has focused mostly on genetically modified mice, although …

The safety of most human recombinant proteins can be evaluated in transgenic mice tolerant
to specific human proteins. However, owing to insufficient genetic diversity and to …

Pig-to-human organ transplantation is a feasible solution to resolve the shortage of organ
donors for patients that wait for transplantation. To overcome immunological rejection, which …

Cardiac xenotransplantation (CXTx) might be a promising approach to bridge the gap
between the supply and demand of a donor heart. The survival of cardiac xenograft has …

This review gives a brief overview of the genetic modifications necessary for grafted porcine
tissues and organs to overcome rejection in human recipients. It then focuses on the …

Retinoic acid-inducible gene I (RIG-I) activates mitochondrial antiviral signaling proteins,
initiating the antiviral response. RIG-I and RNF135, a ubiquitin ligase regulator, are missing …

Simple Summary Osteosarcoma (OS) is a highly heterogenous cancer, making the
identification of genetic driving factors difficult. Genetic factors, such as heritable mutations of …