Betulin, a pentacyclic triterpene and a plant pentacyclic triterpene metabolite, can be found
in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid …

Endothelium is a community of endothelial cells (ECs), which line the blood and lymphatic
vessels, thus forming an interface between the tissues and the blood or lympha. This …

Cancer stem cells (CSCs) are generally dormant or slowly cycling tumor cells that have the
ability to reconstitute tumors. They are thought to be involved in tumor resistance to …

Filopodia,“the fingers that do the walking,” have been identified on endothelial cells at the tip
of sprouting vessels for half a century, but the key role of the tip cell in vessel branching has …

Inflammation and angiogenesis are frequently coupled in pathological situations such as
atherosclerosis, diabetes, and arthritis. The inflammatory response increases capillary …

Aminopeptidase N (CD13) is a widely expressed ectoenzyme with functions that do not
always depend on its enzymatic activity: an aspect that has been overlooked. Numerous …

We investigated the global placental gene expression profile in severe preeclampsia.
Twenty-one women were randomly selected from 50 participants with uncomplicated …

Solid tumors are thought to contain cancer stem cells (CSCs) as a distinct population
responsible for tumor relapse and metastasis due to their abilities to self-renew, differentiate …

Gambogic acid (GA), the main active compound of Gamboge hanburyi, has been previously
reported to activate apoptosis in many types of cancer cell lines by targeting transferrin …

New therapies using novel mechanisms to induce tumor cell death are needed with plants
playing a crucial role as a source for potential anticancer compounds. One highly promising …