Host–parasite co-evolution and its genomic signature
Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …
[HTML][HTML] Advances in the evolutionary understanding of MHC polymorphism
Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the
vertebrate adaptive immune response by presenting peptide antigens on the cell surface …
vertebrate adaptive immune response by presenting peptide antigens on the cell surface …
Dietary input of microbes and host genetic variation shape among-population differences in stickleback gut microbiota
CCR Smith, LK Snowberg… - The ISME …, 2015 - academic.oup.com
To explain differences in gut microbial communities we must determine how processes
regulating microbial community assembly (colonization, persistence) differ among hosts and …
regulating microbial community assembly (colonization, persistence) differ among hosts and …
Evolution of the immune system influences speciation rates in teleost fishes
Teleost fishes constitute the most species-rich vertebrate clade and exhibit extensive genetic
and phenotypic variation, including diverse immune defense strategies. The genomic basis …
and phenotypic variation, including diverse immune defense strategies. The genomic basis …
Infectious disease, shifting climates, and opportunistic predators: cumulative factors potentially impacting wild salmon declines
Emerging diseases are impacting animals under high‐density culture, yet few studies
assess their importance to wild populations. Microparasites selected for enhanced virulence …
assess their importance to wild populations. Microparasites selected for enhanced virulence …
Divergent allele advantage at human MHC genes: signatures of past and ongoing selection
The highly polymorphic genes of the major histocompatibility complex (MHC) play a key role
in adaptive immunity. Divergent allele advantage, a mechanism of balancing selection, is …
in adaptive immunity. Divergent allele advantage, a mechanism of balancing selection, is …
Major H istocompatibility C omplex class II b polymorphism influences gut microbiota composition and diversity
DI Bolnick, LK Snowberg, JG Caporaso… - Molecular …, 2014 - Wiley Online Library
Animals harbour diverse communities of symbiotic bacteria, which differ dramatically among
host individuals. This heterogeneity poses an immunological challenge: distinguishing …
host individuals. This heterogeneity poses an immunological challenge: distinguishing …
Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field
Although crucial for the understanding of adaptive evolution, genetically resolved examples
of local adaptation are rare. To maximize survival and reproduction in their local …
of local adaptation are rare. To maximize survival and reproduction in their local …
HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation
Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic
diversity. A hallmark for balancing selection in humans is the heterozygote advantage at …
diversity. A hallmark for balancing selection in humans is the heterozygote advantage at …
The role of parasitism in adaptive radiations—when might parasites promote and when might they constrain ecological speciation?
A Karvonen, O Seehausen - International Journal of Ecology, 2012 - Wiley Online Library
Research on speciation and adaptive radiation has flourished during the past decades, yet
factors underlying initiation of reproductive isolation often remain unknown. Parasites …
factors underlying initiation of reproductive isolation often remain unknown. Parasites …