Host–parasite co-evolution and its genomic signature

D Ebert, PD Fields - Nature Reviews Genetics, 2020 - nature.com
Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …

[HTML][HTML] Advances in the evolutionary understanding of MHC polymorphism

J Radwan, W Babik, J Kaufman, TL Lenz, J Winternitz - Trends in Genetics, 2020 - cell.com
Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the
vertebrate adaptive immune response by presenting peptide antigens on the cell surface …

Dietary input of microbes and host genetic variation shape among-population differences in stickleback gut microbiota

CCR Smith, LK Snowberg… - The ISME …, 2015 - academic.oup.com
To explain differences in gut microbial communities we must determine how processes
regulating microbial community assembly (colonization, persistence) differ among hosts and …

Evolution of the immune system influences speciation rates in teleost fishes

M Malmstrøm, M Matschiner, OK Tørresen, B Star… - Nature Genetics, 2016 - nature.com
Teleost fishes constitute the most species-rich vertebrate clade and exhibit extensive genetic
and phenotypic variation, including diverse immune defense strategies. The genomic basis …

Infectious disease, shifting climates, and opportunistic predators: cumulative factors potentially impacting wild salmon declines

KM Miller, A Teffer, S Tucker, S Li… - Evolutionary …, 2014 - Wiley Online Library
Emerging diseases are impacting animals under high‐density culture, yet few studies
assess their importance to wild populations. Microparasites selected for enhanced virulence …

Divergent allele advantage at human MHC genes: signatures of past and ongoing selection

F Pierini, TL Lenz - Molecular biology and evolution, 2018 - academic.oup.com
The highly polymorphic genes of the major histocompatibility complex (MHC) play a key role
in adaptive immunity. Divergent allele advantage, a mechanism of balancing selection, is …

Major H istocompatibility C omplex class II b polymorphism influences gut microbiota composition and diversity

DI Bolnick, LK Snowberg, JG Caporaso… - Molecular …, 2014 - Wiley Online Library
Animals harbour diverse communities of symbiotic bacteria, which differ dramatically among
host individuals. This heterogeneity poses an immunological challenge: distinguishing …

Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field

C Eizaguirre, TL Lenz, M Kalbe, M Milinski - Ecology letters, 2012 - Wiley Online Library
Although crucial for the understanding of adaptive evolution, genetically resolved examples
of local adaptation are rare. To maximize survival and reproduction in their local …

HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation

J Arora, F Pierini, PJ McLaren… - Molecular biology …, 2020 - academic.oup.com
Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic
diversity. A hallmark for balancing selection in humans is the heterozygote advantage at …

The role of parasitism in adaptive radiations—when might parasites promote and when might they constrain ecological speciation?

A Karvonen, O Seehausen - International Journal of Ecology, 2012 - Wiley Online Library
Research on speciation and adaptive radiation has flourished during the past decades, yet
factors underlying initiation of reproductive isolation often remain unknown. Parasites …