Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …

Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …

FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …

Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …

The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to …

Bone homeostasis involves bone formation and bone resorption, which are processes that
maintain skeletal health. Oxidative stress is an independent risk factor, causing the …

Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …