Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Irisin is a myokine that leads to increased energy expenditure by stimulating the'browning'of
white adipose tissue. In the first description of this hormone, increased levels of circulating …

Physical exercise has beneficial effects on metabolic diseases, and a combined therapeutic
regimen of regular exercise and pharmaceutical treatment is often recommended for their …

In 2002, a transmembrane protein—now known as FNDC5—was discovered and shown to
be expressed in skeletal muscle, heart, and brain. It was virtually ignored for 10 years, until a …

The prevalence of sarcopenic obesity is increasing worldwide, particularly amongst aging
populations. Insulin resistance is the core mechanism of sarcopenic obesity and is also …

This study compares the effect of two types of exercise training, ie, moderate-intensity
continuous training (MICT) or high-intensity interval training (HIIT) on the browning of …

Exercise has beneficial effects in ameliorating metabolic disorders, and a combined
therapeutic regimen of regular exercise and pharmaceutical treatment is often …

Exercise provides many health benefits, including improved metabolism, cardiovascular
health, and cognition. We have shown previously that FNDC5, a type I transmembrane …

Context: Irisin has been proposed to be a myokine mediating the effect of exercise on
adipocyte browning. The physiology of irisin in humans is not completely understood …