Endometriosis (EMS) is the most common gynecological disease in women of reproductive
age, and it is associated with chronic pelvic pain, dyspareunia and infertility. As a …

Stroke is a severe neurological disorder in humans that results from an interruption of the
blood supply to the brain. Worldwide, stoke affects over 100 million people each year and is …

Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the
therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs). However …

Endometriosis is a chronic inflammatory disease causing distressing symptoms and
requiring a life-long management strategy. The objective of this review is to evaluate …

Many enzymes contain tunnels and gates that are essential to their function. Gates
reversibly switch between open and closed conformations and thereby control the traffic of …

Background and Objectives: Cyclooxygenase-2 (COX-2) is mostly linked to inflammation
and has been validated as a molecular target for treating inflammatory diseases. The …

In recent years, the emergence of biologically active compounds that contain a heterocyclic
ring has gained a great deal of attention among medicinal chemists. Among these …

Cytotoxicity and inflammation-associated toxic responses have been observed to be
induced by bacterial lipopolysaccharides (LPS) in vitro and in vivo respectively. Use of …

Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorder after Alzheimer's disease. Increasing evidence highlights the role of age-related …

We explored the immune neuropathology underlying multi-day relief from neuropathic pain
in a rat model initiated at the sciatic nerve, by using a nanoemulsion-based nanomedicine …