The reactive oxygen species (ROS) form under normal physiological conditions and may
have both beneficial and harmful role. We search the literature and current knowledge in the …

Coronaviruses can cause serious respiratory tract infections and may also impact other end
organs such as the central nervous system, the lung and the heart. The coronavirus disease …

The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Although ascorbic acid is an important water‐soluble antioxidant and enzyme cofactor in
plants and animals, humans and some other species do not synthesize ascorbate due to the …

Mitochondria are at the crossroads of several crucial cellular activities including: adenosine
triphosphate (ATP) generation via oxidative phosphorylation; the biosynthesis of heme …

Age-related macular degeneration (AMD) is a late-onset, neurodegenerative retinal disease
that shares several clinical and pathological features with Alzheimer's disease (AD) …

Neurodegenerative diseases are multifactorial debilitating disorders of the nervous system
that affect approximately 30 millionindividuals worldwide. Neurodegenerative diseases such …

Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in
primary somatic cell culture. It is triggered as a stereotypic response to unrepaired nuclear …

Mitochondria are important integrators of cellular function and therefore affect the
homeostatic balance of the cell. Besides their important role in producing adenosine …