Gamma histone 2AX (γ-H2AX) as a predictive tool in radiation oncology
S Pouliliou, MI Koukourakis - Biomarkers, 2014 - Taylor & Francis
Ionizing radiation cause DNA damage to cells, leading them to cell death via DNA double-
strand breaks (DSBs) formation. DSBs formation is followed immediately by histone H2AX …
strand breaks (DSBs) formation. DSBs formation is followed immediately by histone H2AX …
[HTML][HTML] Microwaves from mobile phone induce reactive oxygen species but not DNA damage, preleukemic fusion genes and apoptosis in hematopoietic stem …
M Durdik, P Kosik, E Markova, A Somsedikova… - Scientific reports, 2019 - nature.com
Exposure to electromagnetic fields (EMF) has been associated with the increased risk of
childhood leukemia, which arises from mutations induced within hematopoietic stem cells …
childhood leukemia, which arises from mutations induced within hematopoietic stem cells …
[HTML][HTML] Biodosimetry of low dose ionizing radiation using DNA repair foci in human lymphocytes
L Jakl, E Marková, L Koláriková, I Belyaev - Genes, 2020 - mdpi.com
Purpose: Ionizing radiation induced foci (IRIF) known also as DNA repair foci represent most
sensitive endpoint for assessing DNA double strand breaks (DSB). IRIF are usually …
sensitive endpoint for assessing DNA double strand breaks (DSB). IRIF are usually …
[HTML][HTML] Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation
S Biechonski, L Olender, A Zipin-Roitman, M Yassin… - Scientific reports, 2018 - nature.com
Failure to precisely repair DNA damage in self-renewing Hematopoietic Stem and early
Progenitor Cells (HSPCs) can disrupt normal hematopoiesis and promote leukemogenesis …
Progenitor Cells (HSPCs) can disrupt normal hematopoiesis and promote leukemogenesis …
Effects of different mobile phone UMTS signals on DNA, apoptosis and oxidative stress in human lymphocytes
S Gulati, P Kosik, M Durdik, M Skorvaga, L Jakl… - Environmental …, 2020 - Elsevier
Different scientific reports suggested link between exposure to radiofrequency radiation (RF)
from mobile communications and induction of reactive oxygen species (ROS) and DNA …
from mobile communications and induction of reactive oxygen species (ROS) and DNA …
Imaging flow cytometry as a sensitive tool to detect low‐dose‐induced DNA damage by analyzing 53 BP 1 and γ H2AX foci in human lymphocytes
M Durdik, P Kosik, J Gursky, L Vokalova… - Cytometry Part …, 2015 - Wiley Online Library
Ionizing radiation induced foci (IRIF) are considered the most sensitive indicator for DNA
double‐strand break (DSB) detection. Monitoring DSB induction by low doses of ionizing …
double‐strand break (DSB) detection. Monitoring DSB induction by low doses of ionizing …
DNA repair foci and late apoptosis/necrosis in peripheral blood lymphocytes of breast cancer patients undergoing radiotherapy
E Marková, A Somsedíková, S Vasilyev… - … journal of radiation …, 2015 - Taylor & Francis
Purpose: Double-strand breaks (DSB) repair and apoptosis are assumed to be key factors in
the determination of individual variability in response to radiation treatment. In this study we …
the determination of individual variability in response to radiation treatment. In this study we …
Radiation Sensitivity of Human CD34+ Cells Versus Peripheral Blood T Lymphocytes of Newborns and Adults: DNA Repair and Mutagenic Effects
C Vandevoorde, A Vral… - Radiation …, 2016 - meridian.allenpress.com
As hematopoietic stem and progenitor cells (HSPCs) self-renew throughout life,
accumulation of genomic alterations can potentially give rise to radiation carcinogenesis. In …
accumulation of genomic alterations can potentially give rise to radiation carcinogenesis. In …
[HTML][HTML] Hematopoietic stem/progenitor cells are less prone to undergo apoptosis than lymphocytes despite similar DNA damage response
M Durdik, P Kosik, J Kruzliakova, L Jakl, E Markova… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Hematopoietic stem/progenitor CD34+ cells (HSPC) give rise to all types of blood cells and
represent a key cellular target for origination of leukemia. Apoptosis and repair of DNA …
represent a key cellular target for origination of leukemia. Apoptosis and repair of DNA …
[HTML][HTML] DNA damage response and preleukemic fusion genes induced by ionizing radiation in umbilical cord blood hematopoietic stem cells
P Kosik, M Durdik, L Jakl, M Skorvaga, E Markova… - Scientific Reports, 2020 - nature.com
There is clear evidence that ionizing radiation (IR) causes leukemia. For many types of
leukemia, the preleukemic fusion genes (PFG), as consequences of DNA damage and …
leukemia, the preleukemic fusion genes (PFG), as consequences of DNA damage and …