The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
[PDF][PDF] Immune Modulation in HIV-Positive Neonates: Insights and Implications for Clinical Management
Neonatal HIV infection presents unique challenges in immune modulation and clinical
management. This review delves into the intricate dynamics of immune modulation in HIV …
management. This review delves into the intricate dynamics of immune modulation in HIV …
Broadly neutralizing antibody treatment maintained HIV suppression in children with favorable reservoir characteristics in Botswana
RL Shapiro, G Ajibola, K Maswabi, M Hughes… - Science translational …, 2023 - science.org
Broadly neutralizing antibodies (bNAbs) may provide an alternative to standard antiretroviral
treatment (ART) for controlling HIV-1 replication and may have immunotherapeutic effects …
treatment (ART) for controlling HIV-1 replication and may have immunotherapeutic effects …
Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers
Increasing evidence suggests that durable drug-free control of HIV-1 replication is enabled
by effective cellular immune responses that may induce an attenuated viral reservoir …
by effective cellular immune responses that may induce an attenuated viral reservoir …
Understanding viral and immune interplay during vertical transmission of HIV: implications for cure
O Amin, J Powers, KM Bricker, A Chahroudi - Frontiers in Immunology, 2021 - frontiersin.org
Despite the significant progress that has been made to eliminate vertical HIV infection, more
than 150,000 children were infected with HIV in 2019, emphasizing the continued need for …
than 150,000 children were infected with HIV in 2019, emphasizing the continued need for …
Longitudinal dynamics of intact HIV proviral DNA and outgrowth virus frequencies in a cohort of individuals receiving antiretroviral therapy
SD Falcinelli, KW Kilpatrick, J Read… - The Journal of …, 2021 - academic.oup.com
Background The replication-competent human immunodeficiency virus (HIV) reservoir is the
major barrier to cure. The quantitative viral outgrowth assay (QVOA), the gold-standard …
major barrier to cure. The quantitative viral outgrowth assay (QVOA), the gold-standard …
An ordeal that does not heal: understanding barriers to a cure for HIV-1 infection
With more than 38 million people living with HIV-1 (PLWH) worldwide, developing a cure for
HIV-1 remains a major global health priority. Lifelong persistence of HIV-1 is frequently …
HIV-1 remains a major global health priority. Lifelong persistence of HIV-1 is frequently …
The clinical effect of point-of-care HIV diagnosis in infants: a systematic review and meta-analysis
Background Timely diagnosis and treatment of HIV is crucial in HIV-exposed infants to
prevent the high rates of mortality seen during the first 2 years of life if HIV is untreated …
prevent the high rates of mortality seen during the first 2 years of life if HIV is untreated …
Why the HIV reservoir never runs dry: clonal expansion and the characteristics of HIV-infected cells challenge strategies to cure and control HIV infection
CY Lau, MA Adan, F Maldarelli - Viruses, 2021 - mdpi.com
Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …
proviral populations in cells that persist for prolonged periods and that can undergo clonal …