Causal relationship between blood metabolites and risk of five infections: a Mendelian randomization study

Z Wei, Q Xiong, D Huang, Z Wu, Z Chen - BMC Infectious Diseases, 2023 - Springer
Objective Infectious diseases continue to pose a significant threat in the field of global public
health, and our understanding of their metabolic pathogenesis remains limited. However …

Understanding Factors That Cause Benign Paroxysmal Positional Vertigo, Ménière Disease, and Vestibular Neuritis: A Two-Sample Mendelian Randomization Study

T Guo, G Jia, D Liu, X Deng, J Li, H Xie - Ear and hearing, 2024 - journals.lww.com
Objectives: Vertigo is a prevalent clinical symptom, frequently associated with benign
paroxysmal positional vertigo (BPPV), Ménière disease (MD), and vestibular neuritis (VN) …

Novel loci and biomedical consequences of iron homoeostasis variation

E Allara, S Bell, R Smith, SJ Keene, D Gill… - Communications …, 2024 - nature.com
Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR)
playing significant roles. However, the genetic determinants of these traits and the …

Circulating micronutrient levels and their association with sepsis susceptibility and severity: a Mendelian randomization study

Z Wei, Y Liu, X Mei, J Zhong, F Huang - Frontiers in Genetics, 2024 - frontiersin.org
Background: Sepsis, a global health challenge, necessitates a nuanced understanding of
modifiable factors for effective prevention and intervention. The role of trace micronutrients in …

Novel loci and biomedical consequences of iron homoeostasis variation

R Popovic, M Fabre, J Schutzman, D Kulkarni… - Communications …, 2024 - jyx.jyu.fi
Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR)
playing significant roles. However, the genetic determinants of these traits and the …

Role of N-acetylkynurenine in mediating the effect of gut microbiota on urinary tract infection: a Mendelian randomization study

Y He, C Han, C Li, X Yin, J Wang, L Gu, R Yan… - Frontiers in …, 2024 - frontiersin.org
Introduction This study explored the causal connections between gut microbiota (GM),
urinary tract infection (UTI), and potential metabolite mediators using Mendelian …

Circulating micronutrient levels and respiratory infection susceptibility and severity: a bidirectional Mendelian randomization analysis

Z Wei, Q Xiong, L Liang, Z Wu, Z Chen - Frontiers in Nutrition, 2024 - frontiersin.org
Background Limited and inconclusive data from observational studies and randomized
controlled trials exist on the levels of circulating micronutrients in the blood and their …

Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling

IF Foote, JP Flint, AE Furtjes, DS Mullin, JD Fisk… - medRxiv, 2024 - medrxiv.org
Frailty is a multifaceted clinical state associated with accelerated aging and adverse health
outcomes. Informed etiological models of frailty hold promise for producing widespread …