Autosomal dominant missense mutations that hyperactivate the leucine-rich repeat protein
kinase-2 (LRRK2) are a common cause of inherited Parkinson's disease and therapeutic …

Rab GTPases comprise a large family of conserved GTPases that are critical regulators of
the secretory and endocytic pathways. The human genome encodes~ 65 Rabs that localize …

Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease.
LRRK2 phosphorylates a subset of Rab GTPases, particularly Rab10 and Rab8A, and we …

Parkinson's disease (PD) is a neurodegenerative, progressive disease without a cure. To
prevent PD onset or at least limit neurodegeneration, a better understanding of the …

Parkinson's disease is one of the most common age-related neurodegenerative disorders.
Although predominantly a motor disorder, cognitive impairment and dementia are important …

Recent studies indicate that CGG repeat expansions in LRP12, GIPC1, and NOTCH2NLC
are associated with oculopharyngodistal myopathy (OPDM) types 1, 2, and 3, respectively …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic
cause of Parkinson's disease (PD), with growing importance also for Crohn's disease and …

Point mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of
familial Parkinson's disease (PD) and are implicated in a significant proportion of apparently …

Protein coding mutations in leucine‐rich repeat kinase 2 (LRRK2) cause familial Parkinson's
disease (PD), and noncoding variations around the gene increase the risk of developing …

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant familial
Parkinson's disease (PD), with pathogenic mutations enhancing LRRK2 kinase activity …