Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids
Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …
aroused great interest in medicinal chemists for the development of new drugs or drug …
DHFR inhibitors: reading the past for discovering novel anticancer agents
Dihydrofolate reductase inhibitors are an important class of drugs, as evidenced by their use
as antibacterial, antimalarial, antifungal, and anticancer agents. Progress in understanding …
as antibacterial, antimalarial, antifungal, and anticancer agents. Progress in understanding …
Diaryl ether: a privileged scaffold for drug and agrochemical discovery
Diaryl ether (DE) is a functional scaffold existing widely both in natural products (NPs) and
synthetic organic compounds. Statistically, DE is the second most popular and enduring …
synthetic organic compounds. Statistically, DE is the second most popular and enduring …
Dihydrofolate reductase inhibitors for use as antimicrobial agents
J He, W Qiao, Q An, T Yang, Y Luo - European journal of medicinal …, 2020 - Elsevier
Drug-resistant bacteria pose an increasingly serious threat to mankind all over the world.
However, the currently available clinical treatments do not meet the urgent demand …
However, the currently available clinical treatments do not meet the urgent demand …
Dihydrofolate reductase inhibitors: Patent landscape and phases of clinical development (2001–2021)
Introduction Dihydrofolate reductase (DHFR) plays an important role in the biosynthesis of
amino acid and folic acid. It participates by reducing dihydrofolate to tetrahydrofolate, in the …
amino acid and folic acid. It participates by reducing dihydrofolate to tetrahydrofolate, in the …
Thiadiazole inhibitors: a patent review
KM Dawood, TA Farghaly - Expert opinion on therapeutic patents, 2017 - Taylor & Francis
Introduction: Four isomeric structures of thiadiazole motifs have outstanding
pharmacological inhibitory applications are reported in this review. Thiadiazole nucleus is …
pharmacological inhibitory applications are reported in this review. Thiadiazole nucleus is …
A novel of azo-thiazole moiety alternative for benzidine-based pigments: design, synthesis, characterization, biological evaluation, and molecular docking study
A new series of coloring compounds (pigments) based on 5-(2-aminothiazol-5-yl) thiazol-2-
amine and 5-(4-aminophenyl) thiazol-2-amine as heterocyclic alternatives for benzidine …
amine and 5-(4-aminophenyl) thiazol-2-amine as heterocyclic alternatives for benzidine …
Novel 1, 2, 4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study
TS Ibrahim, AJ Almalki, AH Moustafa, RM Allam… - Bioorganic …, 2021 - Elsevier
New antibacterial drugs are urgently needed to tackle the rapid rise in multi-drug resistant
bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs …
bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs …
Synthesis, biological evaluation and molecular modeling study of new (1, 2, 4-triazole or 1, 3, 4-thiadiazole)-methylthio-derivatives of quinazolin-4 (3H)-one as DHFR …
A new series of 2-mercapto-quinazolin-4-one analogues was designed, synthesized and
evaluated for their in vitro DHFR inhibition, antitumor and antimicrobial activity. Compound …
evaluated for their in vitro DHFR inhibition, antitumor and antimicrobial activity. Compound …
Synthesis, antiviral activity, 3D-QSAR, and interaction mechanisms study of novel malonate derivatives containing quinazolin-4 (3H)-one moiety
M Chen, P Li, D Hu, S Zeng, T Li, L Jin, W Xue… - Bioorganic & Medicinal …, 2016 - Elsevier
A series of novel malonate derivatives containing quinazolin-4 (3 H)-one moiety were
synthesized and evaluated for their antiviral activities against cucumber mosaic virus (CMV) …
synthesized and evaluated for their antiviral activities against cucumber mosaic virus (CMV) …