The pineal product melatonin has remarkable antioxidant properties. It is secreted during
darkness and plays a key role in various physiological responses including regulation of …

This paper reviews recent work on the biological underpinnings of clinical depression
emphasizing the crucial role of immunoinflammatory and oxidative and nitrosative stress …

Melatonin exerts its actions through membrane MT1/MT2 melatonin receptors, which belong
to the super family of G-protein-coupled receptors consisting of the typical seven …

Substance P plays a pivotal role in human cancer development and progression by binding
to its receptor, neurokinin-1. Neurokinin-1 has 2 isoforms: full-length neurokinin-1 and …

Tachykinins play a critical role in neuroendocrine regulation of reproduction. The best
known members of the family are substance P (SP), neurokinin A and neurokinin B …

Multiple sclerosis (MS) is an immune mediated disorder that is under intensive investigation
in an attempt to improve on available treatments. Many of the changes occurring in MS …

Sulfur mustard (SM) is an important chemical warfare agent. The mechanism of SM toxicity
still has not been fully recognized. However, oxidative stress and following the damaging of …

神经病理性疼痛是由于外周或中枢神经系统的直接损伤和功能紊乱引起的疼痛, 属于慢性疼痛,
表现为自发性疼痛, 痛觉过敏, 异常疼痛和感觉异常等临床特征. 随着神经痛动物模型的建立和 …

The inhalation of engineered nanoparticles stimulates the development of atherosclerosis
and impairs vascular function. However, the cardiac effects of inhaled engineered …

Metabolic dysregulation is intimately associated with a wide array of seemingly unrelated
disorders, including schizophrenia, Alzheimer disease, and depression. Genetic …